[Participation of NMDA receptors in spontaneous burst firing of dopaminergic mesencephalic neurons]
| Autor: | Karima Chergui, Pj, Charléty, Akaoka H, Jl, Brunet, Cf, Saunier, Buda M, Th, Svensson, Chouvet G |
|---|---|
| Přispěvatelé: | Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | francouzština |
| Rok vydání: | 1991 |
| Předmět: |
Male
Neurons MESH: Receptors N-Methyl-D-Aspartate MESH: Rats Dopamine [SDV]Life Sciences [q-bio] MESH: Neurons Action Potentials Rats Inbred Strains MESH: Dopamine MESH: Mesencephalon Receptors N-Methyl-D-Aspartate MESH: Rats Inbred Strains MESH: Male Rats nervous system Mesencephalon Animals MESH: Animals MESH: Action Potentials |
| Zdroj: | Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie, Elsevier, 1991, 313 (2), pp.139-44 Europe PubMed Central |
| Popis: | International audience; In the rat, somatodendritic application of the NMDA antagonist AP-5, within the Substantia Nigra Zona Compacta and Ventral Tegmental Area, either by micro-iontophoresis or pressure ejection, reduces burst firing of dopamine neurons. Similar local application of the non-NMDA antagonist CNQX does not affect their firing pattern. These results indicate that, in vivo, excitatory amino acid afferents participate through NMDA receptors in the control of the spontaneous burst firing of midbrain dopamine neurons. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|