Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 in regulating T cell homeostasis
| Autor: | Salmond, RJ, Brownlie, RJ, Zamoyska, R |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
musculoskeletal diseases
endocrine system diseases T-Lymphocytes Receptors Antigen T-Cell Lymphocyte Activation phosphatase Autoimmune Diseases Mice immune system diseases Lymphopenia Animals Homeostasis Humans RNA Messenger Antigens skin and connective tissue diseases Cell Proliferation Extra View autoimmunity T cell Protein Tyrosine Phosphatase Non-Receptor Type 22 PTPN22 eye diseases Up-Regulation Models Animal signal transduction |
| Zdroj: | Cell Cycle Salmond, R J, Brownlie, R J & Zamoyska, R 2015, ' Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 in regulating T cell homeostasis ', Cell Cycle, vol. 14, no. 5, pp. 705-11 . https://doi.org/10.1080/15384101.2015.1007018 |
| ISSN: | 1551-4005 1538-4101 |
| Popis: | The non-receptor tyrosine phosphatase PTPN22 has a vital function in inhibiting antigen-receptor signaling in T cells, while polymorphisms in the PTPN22 gene are important risk alleles in human autoimmune diseases. We recently reported that a key physiological function of PTPN22 was to prevent naïve T cell activation and effector cell responses in response to low affinity antigens. PTPN22 also has a more general role in limiting T cell receptor-induced proliferation. Here we present new data emphasizing this dual function for PTPN22 in T cells. Furthermore, we show that T cell activation modulates the expression of PTPN22 and additional inhibitory phosphatases. We discuss the implication of these findings for our understanding of the roles of PTPN22 in regulating T cell responses and in autoimmunity. |
| Databáze: | OpenAIRE |
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