Outcome of a screening programme for the prevention of neonatal invasive early-onset group B Streptococcus infection in a UK maternity unit: an observational study
| Autor: | Gopal Rao, G, Nartey, G, McAree, T, O'Reilly, A, Hiles, S, Lee, T, Wallace, S, Batura, R, Khanna, P, Abbas, H, Tilsed, C, Nicholl, R, Lamagni, T, Bassett, P |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Group B Streptococcus
Adult Pregnancy Trimester Third Infant Newborn Diseases Streptococcus agalactiae Young Adult Pregnancy Streptococcal Infections Humans Maternal Health Services Research screening Infant Newborn Historically Controlled Study Paediatrics Prenatal Care neonates United Kingdom Anti-Bacterial Agents early onset infection Female Hospital Units |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | Background Against a background of failure to prevent neonatal invasive early-onset group B Streptococcus infections (GBS) in our maternity unit using risk-based approach for intrapartum antibiotic prophylaxis, we introduced an antenatal GBS carriage screening programme to identify additional women to target for prophylaxis. Objectives To describe the implementation and outcome of an antepartum screening programme for prevention of invasive early-onset GBS infection in a UK maternity unit. Design Observational study of outcome of screening programme (intervention) with comparison to historical controls (preintervention). Setting Hospital and community-based maternity services provided by Northwick Park and Central Middlesex Hospitals in North West London. Participants Women who gave birth between March 2014 and December 2015 at Northwick Park Hospital. Methods Women were screened for GBS at 35–37 weeks and carriers offered intrapartum antibiotic prophylaxis. Screening programme was first introduced in hospital (March 2014) and then in community (August 2014). Compliance was audited by review of randomly selected case records. Invasive early-onset GBS infections were defined through GBS being cultured from neonatal blood, cerebrospinal fluid or sterile fluids within 0–6 days of birth. Main outcome Incidence of early-onset GBS infections. Results 6309 (69%) of the 9098 eligible women were tested. Screening rate improved progressively from 42% in 2014 to 75% in 2015. Audit showed that 98% of women accepted the offer of screening. Recto-vaginal GBS carriage rate was 29.4% (1822/6193). All strains were susceptible to penicillin but 11.3% (206/1822) were resistant to clindamycin. Early onset GBS rate fell from 0.99/1000 live births (25/25276) in the prescreening period to 0.33/1000 in the screening period (Rate Ratio=0.33; p=0.08). In the subset of mothers actually screened, the rate was 0.16/1000 live births (1/6309), (Rate Ratio=0.16; p |
| Databáze: | OpenAIRE |
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