CAR-3 and CA 19-9 serum levels in pancreatic cancer: any differences between two epitopes of the same mucin-like glycoprotein?
Autor: | Meggiato, T, Basso, Daniela, Fabris, C, Fogar, Paola, Panozzo, Mp, Plebani, Mario, Faggian, Diego, Scalon, P, Ferrara, C, DEL FAVERO, Giuseppe |
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Rok vydání: | 1990 |
Předmět: |
Adult
Aged 80 and over Male Digestive System Diseases Mucins Antibodies Monoclonal Middle Aged Neoplasm Proteins Diagnosis Differential Pancreatic Neoplasms Epitopes Pancreatitis ROC Curve Antibody Specificity Predictive Value of Tests Biomarkers Tumor Humans Antigens Tumor-Associated Carbohydrate Female Aged |
Zdroj: | Disease markers. 8(4) |
ISSN: | 0278-0240 |
Popis: | The aim of this study was to compare the utility of two recently identified tumour markers of pancreatic cancer, CA 19-9 and CAR-3, and to ascertain the roles of some factors influencing both antigens. CA 19-9 and CAR-3 were measured in sera of 18 control subjects, 27 patients with pancreatic cancer, 25 with chronic pancreatitis, and 29 with extra-pancreatic diseases. CA 19-9 and CAR-3 were, respectively, found to be increased in 85 per cent and 44 per cent of patients with pancreatic cancer, 28 per cent and 0 per cent with chronic pancreatitis and 72 per cent and 28 per cent with extra-pancreatic diseases. The ROC curves showed that, for any serum value considered, CA 19-9 is more effective than CAR-3 in discriminating between pancreatic cancer and control subjects and chronic pancreatitis. With the combined use of both antigens the results were no better than those given by CA 19-9 alone. Correlations were found between liver function tests and CA 19-9 levels and between cholestasis indices only and CAR-3 values. Our findings show that CAR-3 is not a sufficiently reliable marker of pancreatic cancer, due to its low sensitivity. Nor does it offer any more information than CA 19-9. Both assays are influenced, at least in part, by the extent of the neoplasia. Cholestasis which can greatly influence a serum glycoproteic marker such as CA 19-9, was found also to affect, to a lesser extent, CAR-3, an epitope on the same mucin molecule. |
Databáze: | OpenAIRE |
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