Transcription factors in asthma and COPD

Autor:	Caramori, G., Ito, K., Ian Adcock
Předmět:	Pulmonary Disease Chronic Obstructive Asthma COPD inflammation pro-inflammatory proteins gene transcription factors Asthma COPD inflammation Animals Humans pro-inflammatory proteins gene transcription factors Transcription Factors
Zdroj:	Imperial College London Scopus-Elsevier
Popis:	Inflammation is a central feature of asthma and chronic obstructive pulmonary disease (COPD) and both are characterized by an increased transcription of pro-inflammatory proteins (eg, cytokines, chemokines, growth factors and enzymes). Changes in inflammatory gene transcription are regulated by transcription factors that may therefore play a key role in the pathogenesis of asthma and COPD by amplifying and perpetuating the inflammatory process, and thereby contributing to disease severity and responsiveness to treatment. Several new compounds based on interactions with specific transcription factors or their activation pathways are now in development for the treatment of asthma and COPD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3bb27035a0b03739c738e6aefb626d9c https://app.dimensions.ai/details/publication/pub.1076884691 Zobrazit plný text záznamu