Expression of IL-17 and COX2 gene in peripheral blood leukocytes of vitiligo patients

Autor:	Esmaeili, B., Rezaee, S. A. R., Layegh, P., Afshari, J. T., Dye, P., Karimiani, E. G., fatemeh kalalinia, Rafatpanah, H.
Rok vydání:	2011
Předmět:	Adult Male Adolescent Neutrophils lcsh:R Interleukin-17 Vitiligo lcsh:Medicine macromolecular substances Middle Aged Polymerase Chain Reaction IL-17 Gene Expression Regulation Cyclooxygenase 2 Leukocytes Humans Female Lymphocytes RNA Messenger Child COX2 Real-time PCR
Zdroj:	Scopus-Elsevier Iranian Journal of Allergy, Asthma and Immunology, Vol 10, Iss 2 (2011)
ISSN:	1735-1502
Popis:	Vitiligo is a pigmentation disorder in which inflammatory mediators such as cytokines have a pivotal role in disease's pathogenesis. Interleukin 17 (IL-17A) is a proinflammatory cytokine which is involved in the induction of several proinflamatory mediators such as cyclooxygenase 2 (COX2). The aim of this study was to investigate the gene expression of IL-17 and COX2 in peripheral blood leukocytes of vitiligo's patients. Peripheral blood leukocytes from 15 patients with vitiligo and 15 healthy controls were separated using a gradient density centrifugation method. After total RNA isolation and cDNA synthesis, IL-17 and COX2 gene expression were quantified by real-time polymerase chain reaction (PCR). There were no significant differences in IL-17 and COX2 gene expression in lymphocytes of patients with vitiligo compared with control group (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3b99cffd3fbd5876767052157d151ca5 https://pubmed.ncbi.nlm.nih.gov/21625016 Zobrazit plný text záznamu