Piwi-like 1 protein expression is a prognostic factor for renal cell carcinoma patients

Autor: Stöhr, Christine G., Steffens, Sandra, Polifka, Iris, Jung, Rudolf, Kahlmeyer, Andreas, Ivanyi, Philipp, Weber, Florian, Hartmann, Arndt, Wullich, Bernd, Wach, Sven, Taubert, Helge
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
ISSN: 2045-2322
DOI: 10.1038/s41598-018-38254-3
Popis: The Piwi-like genes belong to the Argonaute gene family and are conserved in plants, animals and humans. In addition to their essential role in the germ line and as stem cell-associated genes, Piwi-like proteins play a role in different cancer types but have yet to be studied in renal cell carcinoma (RCC). We investigated tissue micro arrays (TMAs) with tumor samples of two independent cohorts of RCC patients (N = 265 and N = 345); we used immunohistochemistry to assess the protein expression of Piwi-like 1. Applying an immunoreactive score (IRS), we found Piwi-like 1 positivity (IRS > 0) in 28.3% and 14.8% of the tumors in cohorts 1 and 2, respectively. Piwi-like 1 positivity was correlated with Fuhrman grade, tumor stage and the presence of distant metastasis (P
Databáze: OpenAIRE
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