Association Between Single Nucleotide Polymorphisms of the Interleukin-4 Gene and Atopic Dermatitis
| Autor: | Gharagozlou, M., Behniafard, N., Amirzargar, A. A., Hosseinverdi, S., Sotoudeh, S., Farhadi, E., Khaledi, M., Zahra Aryan, Moghaddam, Z. G., Mahmoudi, M., Aghamohammadi, A., Rezaei, N. |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Genotype Incidence Iran Polymorphism Single Nucleotide Risk Assessment Dermatitis Atopic Cohort Studies Haplotypes Reference Values Case-Control Studies Child Preschool Confidence Intervals Odds Ratio Humans Female Genetic Predisposition to Disease Interleukin-4 Promoter Regions Genetic Alleles |
| Zdroj: | Acta Dermatovenerologica Croatica Volume 23 Issue 2 Scopus-Elsevier |
| ISSN: | 1847-6538 1330-027X |
| Popis: | Atopic dermatitis (AD) is an inflammatory skin disease in which both genetic and environmental factors seem to be involved. Several studies investigated the association of certain genetic factors with AD in different ethnic groups, but conflicting data were obtained. This study was performed to check the possible association between single nucleotide polymorphisms (SNPs) of interleukin 4 (IL-4) and the IL-4 receptor α chain (IL-4Rα) and AD in a group of Iranian patients. The allele and genotype frequencies of genes encoding for IL-4 and IL-4Rα were investigated in 89 patients with AD in comparison with 139 healthy controls, using methods based on polymerase chain reaction sequence-specific primers. The most frequent alleles of IL-4 in patients were T at -1098 (P Key words: atopic dermatitis; polymorphism, single nucleotide; interleukin-4 gene |
| Databáze: | OpenAIRE |
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