Human hookworm infection enhances mycobacterial growth inhibition and associates with reduced risk of tuberculosis infection
| Autor: | O'Shea, M, Fletcher, T, Muller, J, Tanner, R, Matsumiya, M, Bailey, J, Jones, J, Smith, S, Koh, G, Horsnell, W, Beeching, N, Dunbar, J, Wilson, D, Cunningham, A, McShane, H |
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| Přispěvatelé: | School of computing [UTAH], University of Utah, Pacific Northwest National Laboratory (PNNL), Le Studium Loire Valley Institute for Advanced Studies, 45000 Orléans, France, Immunologie et Neurogénétique Expérimentales et Moléculaires (INEM), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), University of Oxford [Oxford], This project has been supported by LE STUDIUM Loire Valley Institute for Advanced Studies, Orléans & Tours, France with funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 665790, Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO) |
| Rok vydání: | 2018 |
| Předmět: |
Ancylostomatoidea
Male Adolescent [SDV]Life Sciences [q-bio] Immunology education growth inhibition Feces Hookworm Infections Young Adult Nepal Risk Factors parasitic diseases latent tuberculosis Animals Humans eosinophil Longitudinal Studies Prospective Studies Original Research Gene Expression Profiling Mycobacterium tuberculosis bacterial infections and mycoses LTBI Eosinophils tuberculosis [SDV.IMM]Life Sciences [q-bio]/Immunology hookworm |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Frontiers, 2018, 9, ⟨10.3389/fimmu.2018.02893⟩ FRONTIERS IN IMMUNOLOGY |
| ISSN: | 1664-3224 |
| Popis: | Soil-transmitted helminths and Mycobacterium tuberculosis frequently coincide geographically and it is hypothesized that gastrointestinal helminth infection may exacerbate tuberculosis (TB) disease by suppression of Th1 and Th17 responses. However, few studies have focused on latent TB infection (LTBI), which predominates globally. We performed a large observational study of healthy adults migrating from Nepal to the UK (n = 645). Individuals were screened for LTBI and gastrointestinal parasite infections. A significant negative association between hookworm and LTBI-positivity was seen (OR = 0.221; p = 0.039). Hookworm infection treatment did not affect LTBI conversions. Blood from individuals with hookworm had a significantly greater ability to control virulent mycobacterial growth in vitro than from those without, which was lost following hookworm treatment. There was a significant negative relationship between mycobacterial growth and eosinophil counts. Eosinophil-associated differential gene expression characterized the whole blood transcriptome of hookworm infection and correlated with improved mycobacterial control. These data provide a potential alternative explanation for the reduced prevalence of LTBI among individuals with hookworm infection, and possibly an anti-mycobacterial role for helminth-induced eosinophils. Wellcome Trust; British Lung Foundation; National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Emerging and Zoonotic Infections at the University of Liverpool in partnership with Public Health England (PHE), in collaboration with the Liverpool School of Tropical Medicine; Liverpool School of Tropical Medicine. |
| Databáze: | OpenAIRE |
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