| Autor: |
Yuan, Guosheng, Zhou, Yuchen, Liu, Junwei, Hu, Chengguang, Huang, Huaping, Ren, Yanyu, Yu, Wenxuan, Guo, Yabin, Zhang, Yong-Yuan, Zhou, Yuanping |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
International journal of clinical and experimental pathology. 12(4) |
| ISSN: |
1936-2625 |
| Popis: |
Objective: The aim of this study was to assess AFP response in chronic hepatitis B (CHB) patients with baseline positive AFP (≥7 ng/mL) who received antiviral therapy thereafter. Methods: A cohort study was conducted to assess AFP response in CHB patients who had baseline positive AFP and got antiviral therapy. Results: This retrospective study enrolled 302 antiviral-treatment-naïve CHB patients with positive AFP. After a 12-month antiviral treatment, 144 patients normalized AFP during follow-up while the rest remained AFP-positive. There were no significant differences in baseline characteristics and virologic and ALT responses to antiviral therapy between the two groups. During a mean follow-up of 34 ± 6 months, 16 patients (5.3%) in this cohort developed HCC, and 14 (8.9%) of them emerged in the AFP positive group. There was a significant difference (P=0.004) in HCC occurrence between AFP normalized and non-normalized groups after treatment. Univariate and multivariate analyses revealed that cirrhosis (HR=9.983, 95% CI=3.609-27.617, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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