Herpes simplex virus encephalitis in hamadan, iran
| Autor: | Sabouri Ghannad, M., Solgi, G., Hashemi, S. H., Zebarjady-Bagherpour, J., Hemmatzadeh, A., mehrdad hajilooi |
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| Rok vydání: | 2014 |
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| Zdroj: | Iranian Journal of Microbiology Scopus-Elsevier Iranian Journal of Microbiology, Vol 5, Iss 3 (2013) |
| ISSN: | 2008-3289 |
| Popis: | Background and Objectives: Encephalitis can cause a severe public health problem. The main aim of this research was to evaluate the medical laboratory results of patients with Herpes Simplex Virus (HSV) encephalitis. Materials and Methods: Diagnosis of encephalitis for these patients was firstly based on a clinical profile for Herpes Simplex Encephalitis (HSE), plus either a detected HSV1&2-DNA by PCR in CSF or brain neuro-imaging results. Results: Molecular testing on CSF showed that 15 patients (15%) had HSV infection, 5 patients (5%) had Varicella Zoster Virus (VZV) and one case was positive for Human Immunodeficiency Virus (HIV)-RNA in CSF. The cause of encephalitis in 79 out of 100 patients (79%) was unknown. The comparison of CSF analysis in HSV positives and negatives showed a significant increase of glucose and protein levels in HSV positives than negatives. The mortality rate was 46.6% (7/15) in patients with HSV encephalitis compared to 11.4% (10/85) in non-HSV encephalitis (P = 0.003). Conclusions: In the current study, 15% of cases were diagnosed as having HSV. |
| Databáze: | OpenAIRE |
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