Thromboelastographic profiles as a tool for thrombotic risk in digestive tract cancer
| Autor: | Papa, M. L., Capasso, F., Pudore, L., Torre, S., Mango, S., Russo, V., Delrio, P., Palaia, R., Ruffolo, F., D Eufemia, M. D., Lucia, D., Mariasanta Napolitano, Di Micco, P., Parisi, V. |
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| Přispěvatelé: | Papa, M L, Capasso, F, Pudore, L, Torre, S, Mango, S, Russo, V, Delrio, P, Palaia, R, Ruffolo, F, d'Eufemia, M D, De Lucia, D, Napolitano, M, Di Micco, P, Parisi, V |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Kinetic
Male Original contributions Risk Factor Carcinoma Sex Factor Blood Coagulation Test Middle Aged Thrombelastography Kinetics Sex Factors Reference Values Risk Factors Stomach Neoplasms Stomach Neoplasm Case-Control Studies Area Under Curve Thromboembolism Humans Female Reference Value Blood Coagulation Tests Case-Control Studie Aged Human |
| Zdroj: | Scopus-Elsevier |
| Popis: | Background: Quantification of the magnitude of thrombotic risk associated with malignancy and with anti-cancer therapy is indispensable to use anticoagulant drugs which selectively interfere with haemostatic mechanisms protecting patients from venous thromboembolism (VTE) and probably from tumor progression. However, none of activation coagulation markers has any predictive value for the occurrence of the thrombotic events in one individual patient. Current clotting methods can’t reveal the overall dynamic clot formation; in contrast thromboelastographic methods specifically assess overall coagulation kinetics and its strength in whole blood. Aim: Objective of study was to evaluate if the activation of coagulation as eventually revealed by ROTEM® thromboelastometry could assess an hypercoagulable state in surgical neoplastic patients. Patients and Methods: Fifty consecutive patients with carcinoma of the digestive tract in preoperative period (23 M, 27 F aging 61.5 (45–79 years) and 147 healthy subjects (71 M, 76 F) were studied. A recent thromboelastometric method based on thrombelastography after Hartert was employed. Measurements were performed on ROTEM Coagulation Analyzer. The continuous coagulation data from 50 min course were transformed into dynamic velocity profiles of WB clot formation. Results: Standard parameters (CT, CFT, MCF) of cancer patients were similar to controls. CT (in cancer patients): females 50 s (38.3–58.7), males 50 s (42–71.2) vs 51 s (42–59), p = 0.1210 / 53 s (42–74.8), p = 0.1975 (in controls). CFT (in cancer patients): females 72 s (32- 92.4), males 80 s (50.2- 128.7) vs 78 s (62–100), p = 0.0128 / 80 s (59–124.4), p = 0.9384 (in controls). MCF (in cancer patients): females 70 mm (59.9–82.5), males 63 mm (56–73.7) vs 69 mm (59–95.8), p = 0.9911 / 69 mm (53.6–90), p = 0.0135 (in controls). Females showed a higher MaxVel when compared to males. The MaxVel was increased in cancer patients: females 19 mm /100 s (14.3–49.5) males 18 mm / 100 s (11–27) vs 15 mm 100 s (11.8–22), p < 0.001 / 13 mm / 100 s (10–21.8), p < 0.001 in controls .The t-MaxVel was shortened in cancer patients: females 65 s (48.6–112.8), males 81 s (50.1–135.9) vs 115 s (56.8–166), p |
| Databáze: | OpenAIRE |
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