Blockade of acute grade IV skin and eye graft-versus-host disease by anti-interleukin-2 receptor monoclonal antibody in genoidentical bone marrow transplantation setting
| Autor: | Ozsahin, H., Tuchschmid, P., Roger Lauener, Waldvogel, K., Nadal, D., Seger, R. A. |
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| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
Male
ddc:618 Eye Diseases Skin Diseases/etiology/therapy Herpes Zoster/etiology beta-Thalassemia Eye Diseases/etiology/therapy Antibodies Monoclonal Graft vs Host Disease Receptors Interleukin-2 Antibodies Monoclonal/therapeutic use Herpes Zoster Skin Diseases Bone Marrow Transplantation/adverse effects surgical procedures operative Beta-Thalassemia/therapy Recurrence Acute Disease Graft vs Host Disease/etiology/therapy Receptors Interleukin-2/drug effects Humans Immunosuppressive Agents/therapeutic use Child Immunosuppressive Agents Bone Marrow Transplantation |
| Zdroj: | Turkish Journal of Pediatrics, Vol. 40, No 2 (1998) pp. 231-5 Scopus-Elsevier |
| ISSN: | 0041-4301 |
| Popis: | A six-year-old boy with homozygous beta-thalassemia in the favorable class 1 risk group received a bone marrow transplant, from his histocompatible sister. He developed grade IV skin and eye graft-versus-host disease (GVHD) following varicella zoster reactivation. Despite the appropriate prophylactic use of cyclosporin A (CsA), methotrexate (MTX), and prompt treatment with high-dose steroids, GVHD progressed resulting in total body epidermal necrolysis. Anti-IL-2 receptor monoclonal antibodies (anti-IL-2R moAb) in combination with steroids were administered to selectively block the activated T cells. After 27 days of daily administration, followed by 17 doses of alternate-day therapy with anti-IL-2R moAb, the severe skin and eye GVHD resolved. The patient, at two years posttransplant, has full engraftment and immune reconstitution without chronic GVHD (cGVHD). In conclusion, we suggest that in the HLA-genoidentical bone marrow transplantation setting, very severe and steroid-resistant GVHD can be controlled through the use of anti-IL-2 receptor antibodies which specifically block the activated IL-2 receptor expressing T cells. |
| Databáze: | OpenAIRE |
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