The intrathymic crossroads of T and NK cell differentiation
| Autor: | Klein Wolterink, Roel G J, García-Ojeda, Marcos E, Vosshenrich, Christian A. J., Hendriks, Rudi W, Di Santo, James P. |
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| Přispěvatelé: | Department of Pulmonary Medicine, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Immunité Innée, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), School of Natural Sciences, University of California [Merced] (UC Merced), University of California (UC)-University of California (UC), R. K. W. is supported by grants from the Huygens Scholarship Program and the Royal Netherlands Academy of Arts and Sciences. Research in the Innate Immunity Unit is provided by grants from the Institut Pasteur, Inserm, Fondation pour la Recherche Médicale, InCa Ile-de-France and the Bill and Melinda Gates Foundation through the Grand Challenges in Global Health Program., Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), University of California [Merced], University of California-University of California, Martin, Marie |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
MESH: Cell Differentiation
MESH: Killer Cells Natural T-Lymphocytes Thymus Gland MESH: Models Immunological [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity Animals Humans Cell Lineage MESH: Animals [SDV.IMM.II] Life Sciences [q-bio]/Immunology/Innate immunity MESH: Myeloid Progenitor Cells Myeloid Progenitor Cells MESH: Cytokines MESH: Humans Models Immunological Cell Differentiation MESH: Thymus Gland MESH: Transcription Factors Lymphoid Progenitor Cells MESH: Cell Lineage Killer Cells Natural MESH: T-Lymphocytes MESH: Lymphoid Progenitor Cells Cytokines Transcription Factors |
| Zdroj: | Immunological Reviews Immunological Reviews, 2010, 238 (1), pp.126-37. ⟨10.1111/j.1600-065X.2010.00960.x⟩ Immunological Reviews, Wiley, 2010, 238 (1), pp.126-37. ⟨10.1111/j.1600-065X.2010.00960.x⟩ |
| ISSN: | 0105-2896 1600-065X |
| DOI: | 10.1111/j.1600-065X.2010.00960.x⟩ |
| Popis: | International audience; T lymphocytes depend on the thymic microenvironment for initiation of the T-cell developmental program. As the progenitors in the thymus have lost the capacity to self-renew, this process depends on the constant influx of hematopoietic progenitors that originate in the bone marrow. Nevertheless, thymic emigrants are heterogeneous and retain developmental plasticity for both the myeloid and lymphoid lineages. It is the role of the thymic microenvironment to steer these uncommitted progenitors toward a T-cell fate. Still, the thymus also generates a unique population of thymic NK cells, thus raising the question of how the T versus NK lymphoid cell fate is determined intrathymically. Many factors have been implicated in the developmental pathways in the thymus, and the processes are characterized by both subtle and not so subtle modifications in gene expression. In this review, we consider the crucial factors governing lineage determination of T cells versus NK cells from bi-potent thymic NK/T precursors. Recent reports have shed new light on the complex interactions of cytokines and transcription factors at different cell fate decision branch points in thymopoiesis. We discuss the implications of these findings and propose a model that may be applicable at this critical thymic NK/T juncture. |
| Databáze: | OpenAIRE |
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