| Autor: |
Ximena, Valladares, Rafael, Benavente, Christine, Rojas, Camila, Peña, Rodrigo, Valenzuela, Virginia, Monardes, Hernán, López, Marcelo, Abarca, Pilar, León, Rocío, Osorio, Erika, Pérez, Pablo, Soto, Gabriel La, Rocca, Daniela, Cardemil, Vivianne, Torres, Marvila, Intriago, María Elena, Cabrera, María Soledad, Undurraga |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Revista medica de Chile. 149(11) |
| ISSN: |
0717-6163 |
| Popis: |
Philadelphia-negative myeloproliferative neoplasms (Ph-MPN) are chronic hematological disorders characterized by the overproduction of one or more mature myeloid blood cell lineages. Classical Ph-MPN are polycythemia vera (PV), essential thrombocytopenia (ET) and primary myelofibrosis (PMF).To assess the epidemiological, clinical and diagnostic characteristics of Ph-MPN in Chile.Retrospective review of medical records of all patients referred as MPN from 2012 to 2017. Patients with (9;21) translocation were excluded.Data of 462 cases with a median age of 69 years from 10 public hospitals was reviewed. ET was the most frequently Ph-MNP found. The incidence of Ph-MPN was 1.5 x 100.000 cases. The JAK2 V617F mutation study was performed in 96% of patients and only 30% had a bone marrow biopsy. Thrombotic events were observed in 29% of patients. Bleeding events were observed in 7%. Five-year overall survival was 87%.ET is the most frequent Ph-MPN. The mean incidence was lower than reported in the literature, in part because of a sub diagnosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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