Hematological Improvement of Patients with Active Rheumatoid Arthritis by β-D-Mannuronic Acid (M2000) as a Novel NSAID with Immunosuppressive Property
| Autor: | Ahmadi, H., Jamshidi, A. R., Mahmoudi, M., Gharibdoost, F., Vojdanian, M., Mohammad Javad Fattahi, Rastkari, N., Aghazadeh, Z., Mirshafiey, A. |
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| Rok vydání: | 2017 |
| Předmět: |
Inflammation
M2000 Adult Erythrocyte Indices Male Hexuronic Acids lcsh:R Anti-Inflammatory Agents Non-Steroidal lcsh:Medicine Anemia Interleukin Middle Aged Arthritis Rheumatoid Leukocyte Count Treatment Outcome Cytokines Humans Female Mannuronic acid Rheumatoid arthritis Inflammation Mediators Biomarkers Immunosuppressive Agents Aged |
| Zdroj: | Scopus-Elsevier Iranian Journal of Allergy, Asthma and Immunology, Vol 16, Iss 5 (2017) |
| ISSN: | 1735-1502 |
| Popis: | The aim of this study was to investigate the effect of β-D-mannuronic acid (M2000) on hematological parameters in patients with active rheumatoid arthritis. This study was conducted on 25 patients with active rheumatoid arthritis (RA) (identifier: IRCT2014011213739N2). M2000 was administered orally for anemic and non-anemic RA patients at a dose of 500 mg twice daily for 12 weeks. The patients were permitted to continue the conventional treatments excluding NSAIDs. Blood samples were collected at baseline, 4 and 12 weeks after drug administration and were tested for hematological parameters. Moreover, serum levels of TNF-α and IL-6 were analysed before and after M2000 therapy compared to healthy controls using enzyme linked immunosorbent assay method. We found a significant increase in the count of red blood cells and also hemoglobin (Hb) concentration (0.9 g/dL) in anemic patients after 12 weeks of M2000 therapy (p |
| Databáze: | OpenAIRE |
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