Association between Striatal Brain Iron Deposition, Microbleeds and Cognition 1 Year After a Minor Ischaemic Stroke
Autor: | Valdés Hernández, Maria del C., Case, Tessa, Chappell, Francesca M., Glatz, Andreas, Makin, Stephen, Doubal, Fergus, Wardlaw, Joanna M. |
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Rok vydání: | 2019 |
Předmět: |
Male
cognition QH301-705.5 Iron Severity of Illness Index Article Cohort Studies lcsh:Chemistry Humans brain microbleeds cardiovascular diseases Biology (General) lcsh:QH301-705.5 QD1-999 iron deposits Aged Cerebral Hemorrhage Middle Aged white matter hyperintensities Magnetic Resonance Imaging Corpus Striatum Stroke Chemistry lcsh:Biology (General) lcsh:QD1-999 Ischemic Attack Transient ageing Cerebral Small Vessel Diseases Female MRI |
Zdroj: | International Journal of Molecular Sciences Valdés Hernández, M, Case, T, Chappell, F, Glatz, A, Makin, S, Doubal, F & Wardlaw, J 2019, ' Association between Striatal Brain Iron Deposition, Microbleeds and Cognition 1 Year After a Minor Ischaemic Stroke ', International Journal of Molecular Sciences, vol. 20, no. 6, pp. 1293 . https://doi.org/10.3390/ijms20061293 Volume 20 Issue 6 International Journal of Molecular Sciences, Vol 20, Iss 6, p 1293 (2019) Multidisciplinary Digital Publishing Institute DOAJ-Articles PubMed Central |
ISSN: | 1422-0067 1661-6596 |
DOI: | 10.3390/ijms20061293 |
Popis: | Brain iron deposits (IDs) are inversely associated with cognitive function in community-dwelling older people, but their association with cognition after ischemic stroke, and whether that differs from microbleeds, is unknown. We quantified basal ganglia IDs (BGID) and microbleeds (BMBs) semi-automatically on brain magnetic resonance images from patients with minor stroke (NIHSS < 7), at presentation and 12 months after stroke. We administered the National Adult Reading Test (NART, estimates premorbid or peak adult cognition) and the Revised Addenbrooke&rsquo s Cognitive Examination (ACE-R current cognition) at 1 and 12 months after stroke. We adjusted analyses for baseline cognition, age, gender, white matter hyperintensity (WMH) volume and vascular risk factors. In 200 patients, mean age 65 years, striatal IDs and BMBs volumes did not change over the 12 months. Baseline BGID volumes correlated positively with NART scores at both times (&rho = 0.19, p < 0.01). Baseline and follow-up BGID volumes correlated positively with age (&rho = 0.248, p < 0.001 and &rho = 0.271, p < 0.001 respectively), but only baseline (and not follow-up) BMB volume correlated with age (&rho = 0.129, p < 0.05). Both smoking and baseline WMH burden predicted verbal fluency and visuospatial abilities scores (B = &minus 1.13, p < 0.02 and B = &minus 0.22, p = 0.001 respectively) at 12 months after stroke. BGIDs and BMBs are associated differently with cognition post-stroke studies of imaging and post-stroke cognition should adjust for premorbid cognition. The positive correlation of BGID with NART may reflect the lower premorbid cognition in patients with stroke at younger vs older ages. |
Databáze: | OpenAIRE |
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