Apoptotic and proliferative activity of mouse gastric mucosa following oral administration of fumonisin B1

Autor:	Alizadeh, A. M., Mohammadghasemi, F., Kazem Zendehdel, Kamyabi-Moghaddam, Z., Tavassoli, A., Amini-Najafi, F., Khosravi, A.
Předmět:	Mice Gastric atrophy lcsh:R food and beverages lcsh:Medicine Original Article Apoptosis Apoptosis Fumonisin B1 Gastric atrophy Mice Proliferative activity Fumonisin B1 Proliferative activity
Zdroj:	Scopus-Elsevier Iranian Journal of Basic Medical Sciences Iranian Journal of Basic Medical Sciences, Vol 18, Iss 1, Pp 8-13 (2015)
Popis:	Objective(s): Fumonisins are a group of toxic and carcinogenic mycotoxins, which contaminate the grains and their products. The aim of this study was to examine the apoptotic and proliferative activity of mouse gastric mucosa following administration of fumonisin B1 (FB1). Materials and Methods: Twenty-nine female mice divided into treatment (n=15) and control (n=14) groups. The treatment group received FB1 (150 mg/kg diet) for 16 weeks. The gastric atrophy was allocated using grading criteria modeled on the updated Sydney System. Immunohistochemistry studies were performed for evaluation of apoptosis and proliferative activity in gastric mucosa. Results: Mild to moderate gastric atrophy were observed in microscopic findings of the gastric mucosa in treated animals (P
Databáze:	OpenAIRE
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