| Autor: |
Shawn, Dason, Nathan C, Wong, Timothy F, Donahue, Andreas, Meier, Junting, Zheng, Lorenzo, Mannelli, Pier Luigi, Di Paolo, Lucas W, Dean, Victor A, McPherson, Jonathan E, Rosenberg, Dean F, Bajorin, Marinella, Capeanu, Guido, Dalbagni, H Alberto, Vargas, Bernard H, Bochner |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
J Urol |
| Popis: |
PURPOSE: To determine the diagnostic performance of (18)F-FDG PET/CT for detecting nodal metastases in patients with muscle-invasive urothelial bladder cancer prior to radical cystectomy. MATERIALS AND METHODS: Preoperative (18)F-FDG PET/CT scans (n = 208) were retrospectively reviewed. Scans were routinely performed in 185 patients with muscle-invasive urothelial bladder cancer between August 2012 and February 2017, all of whom underwent radical cystectomy and pelvic lymph node dissection. Analyses were stratified by clinical node involvement and chemotherapy status. The diagnostic performance of (18)F-FDG PET/CT was assessed according to sensitivity, specificity, positive predictive value, and negative predictive value. RESULTS: Lymph node metastases at time of PLND were present in 21.8% of those without suspicious nodes on computed tomography (clinically node negative) and 52.6% of those with suspicious nodes on CT (clinically node positive). Median metastatic focus size was 5 mm. In clinically node negative patients, (18)F-FDG PET/CT rarely detected nodal metastases (sensitivity 7–23%). In clinically node positive patients, a negative (18)F-FDG PET/CT was useful in ruling out lymph node metastases (sensitivity 92–100%). This study was limited by its mixed population and focus on pelvic nodal metastases only. CONCLUSIONS: (18)F-FDG PET/CT appears to be most useful for better characterization of enlarged nodes identified by CT. Routine preoperative (18)F-FDG PET/CT has limited utility in clinically node-negative patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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