[How to estimate glomerular filtration rate in the context of drug dosage adaptation ?]
| Autor: | Delanaye, Pierre, Bouquegneau, Antoine, Moranne, Olivier, Cavalier, Étienne |
|---|---|
| Přispěvatelé: | Centre Hospitalier Universitaire de Liège (CHU-Liège), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes) |
| Jazyk: | francouzština |
| Rok vydání: | 2020 |
| Předmět: |
MESH: Glomerular Filtration Rate
MESH: Humans Creatinine MESH: Renal Insufficiency Chronic Humans MESH: Creatinine Renal Insufficiency Chronic urologic and male genital diseases [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology reproductive and urinary physiology female genital diseases and pregnancy complications Glomerular Filtration Rate |
| Zdroj: | Revue medicale suisse Revue medicale suisse, 2020, 16 (703), pp.1489-1493 |
| Popis: | In chronic kidney disease (CKD) patients, the dosage of many medications should be adapted according to the glomerular filtration rate (GFR). GFR estimation is obtained by using creatinine-based equations. Many different equations have been proposed in the literature, and they don't systematically lead to the same result in terms of drug dosage. There is an ongoing debate to determine which equations should be recommended, with the Cockcroft equation on one side and the MDRD (« Modified Diet in Renal Diseases ») or CKD-EPI (« Chronic Kidney Disease Epidemiology ») on the other side. The last two equations are especially used by nephrologists whereas the Cockcroft is still considered by geriatrists and pharmacologists. In the current article, we discuss the pro/cons from both sides, and propose recommendation for the clinical practice.En cas de maladie rénale chronique, il convient d’ajuster la dose des médicaments au débit de filtration glomérulaire (DFG). L’estimation du DFG est obtenue à partir de formules basées sur la mesure de la créatinine sérique. Plusieurs formules existent dans la littérature et elles n’aboutissent pas toujours à la même conclusion en termes d’adaptation posologique. Le débat dans la littérature sur le choix de la formule se pose entre celle de Cockcroft et Gault et celles appelées |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|