Human papillomavirus genotype distribution in high grade cervical lesions (CIN 2/3) in France: EDITH study

Autor: Prétet , Jean-Luc, Jacquard , Anne-Carole, Carcopino , Xavier, Monnier-Benoit , Sylvain, Averous , Gerlinde, Soubeyrand , Benoit, Leocmach , Yann, Mougin , Christiane, Riethmuller , Didier, Renseigné , Non
Přispěvatelé: Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC )
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Adult
Risk
MESH : Retrospective Studies
Genotype
MESH : Prevalence
MESH : Risk
MESH : Uterine Cervical Neoplasms
MESH : Aged
Uterine Cervical Neoplasms
MESH : Genotype
[SDV.CAN]Life Sciences [q-bio]/Cancer
MESH : Cervical Intraepithelial Neoplasia
Cancer Vaccines
MESH: Cancer Vaccines
[ SDV.CAN ] Life Sciences [q-bio]/Cancer
MESH: Genotype
MESH : Precancerous Conditions
MESH: Papillomaviridae
Prevalence
Humans
MESH : Female
MESH : Middle Aged
MESH : France
MESH : Papillomaviridae
Papillomaviridae
MESH: Prevalence
Aged
Retrospective Studies
MESH: Aged
MESH: Risk
MESH: Humans
MESH: Middle Aged
MESH : Humans
MESH : Cancer Vaccines
virus diseases
MESH: Adult
MESH: Retrospective Studies
MESH : Adult
Middle Aged
Uterine Cervical Dysplasia
female genital diseases and pregnancy complications
MESH: Uterine Cervical Neoplasms
MESH: France
MESH: Precancerous Conditions
Female
France
MESH: Cervical Intraepithelial Neoplasia
Precancerous Conditions
MESH: Female
Zdroj: International Journal of Cancer
International Journal of Cancer, Wiley, 2008, 122 (2), pp.424-7. ⟨10.1002/ijc.23093⟩
International Journal of Cancer, Wiley, 2008, 122 (2), pp.424-7. 〈10.1002/ijc.23093〉
ISSN: 0020-7136
1097-0215
DOI: 10.1002/ijc.23093⟩
Popis: International audience; High grade cervical intraepithelial neoplasia (CIN 2/3) have a high potential to progress to invasive cervical cancer (ICC). Pap testing including follow-up and treatment of CIN 2/3 is currently the best prevention of ICC, but is associated with morbidity, namely obstetrical adverse effects and psychological distress. Human papillomavirus (HPV) is universally accepted as the necessary cause of ICC. The objective of the present study was to describe the type-specific prevalence of HPV in CIN 2/3 in France and hereby to locally estimate the potential benefit of an HPV 16/18 L1 virus-like particles (VLP) vaccine. A total of 493 formalin-fixed and paraffin-embedded CIN 2/3 specimens were analyzed. Medical records were examined for patient related data. HPV were genotyped with the INNO-LiPA assay allowing the detection of 24 HPV genotypes. The overall prevalence of LiPA detectable HPV was 98%. The most prevalent genotype was HPV 16 (62%) followed by HPV 31 (15%), 33 (12%), 52 (9%), 51 (8%), 58 (7%), 35 and 18 (4%). Multiple infection with at least two different high-risk (HR) HPV genotypes was observed in 26% of all specimens including 2.6% with HPV 16 and 18 multiple infections. The present study indicates that HPV 16 is by far the most common HPV type associated with CIN 2/3 in France. With an HPV 16 and 18 prevalence of 64%, HPV 16/18 L1 VLP vaccines would be expected to significantly reduce the burden associated with the management and treatment of CIN 2/3 in France.
Databáze: OpenAIRE
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