Comparison of electric- and magnetic-cardiograms produced by myocardial ischemia in models of the human ventricle and torso
| Autor: | Perez Alday, EA, Ni, H, Zhang, C, Colman, MA, Gan, Z, Zhang, H |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Cardiac Ventricles
Physiology Heart Ventricles Myocardial Ischemia Action Potentials Neurophysiology lcsh:Medicine Research and Analysis Methods Models Biological Sensitivity and Specificity Vascular Medicine Membrane Potential Electrocardiography Ischemia Medicine and Health Sciences Humans Computer Simulation Myocytes Cardiac cardiovascular diseases lcsh:Science Cells Cultured Magnetocardiography Physics Simulation and Modeling Myocardium Electrophysiological Techniques lcsh:R Magnetism Torso Biology and Life Sciences Heart Condensed Matter Physics Electrophysiology Bioassays and Physiological Analysis Magnetic Fields Physical Sciences Cardiovascular Anatomy lcsh:Q Cardiac Electrophysiology Anatomy Algorithms Research Article Neuroscience |
| Zdroj: | PLoS ONE, Vol 11, Iss 8, p e0160999 (2016) Perez Alday, E A, Ni, H, Zhang, C, Colman, M A, Gan, Z & Zhang, H 2016, ' Comparison of Electric-and Magnetic-Cardiograms Produced by Myocardial Ischemia in Models of the Human Ventricle and Torso ', P L o S One . https://doi.org/10.1371/journal.pone.0160999 PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0160999 |
| Popis: | Myocardial ventricular ischemia arises from a lack of blood supply to the heart, which may cause abnormal repolarization andexcitation wave conduction patterns in the tissue, leading to cardiac arrhythmias and even sudden death. Current diagnosis ofcardiac ischemia by the 12leadelectrocardiogram (ECG) has limitations as they are insensitive in many cases and may showunnoticeable differences to normal patterns. As the magnetic field provides extra information on cardiac excitation and is moresensitive to tangential currents to the surface of the chest, whereas the electric field is more sensitive to flux currents, it has beenhypothesized that the magnetocardiogram (MCG) may provide a complementary method to the ECG in ischemic diagnosis.However, it is unclear yet about the differences in sensitivity regions of body surface ECG and MCG signals to ischemic conditions.The aim of this study was to investigate such differences by using 12,36ECGand 36MCGcomputed from multiscalebiophysically detailed computational models of the human ventricles and torso in both control and ischemic conditions. It wasshown that ischemia produced changes in the ECG and MCG signals in the QRS complex, Twaveand STsegment,with greaterrelative differences seen in the 36leadECG and MCG as compared to the 12leadsECG (34% and 37% vs 26%, respectively).The 36leadECG showed more averaged sensitivity than the MCG in the change of Twavedue to ischemia (37% vs 32%,respectively), whereas the MCG showed greater sensitivity than the ECG in the change of the STsegment(50% vs 40%,respectively). In addition, both MCG and ECG showed regionaldependentchanges to ischemia, but with MCG showing a strongercorrelation between ischemic region in the heart. In conclusion, MCG shows more sensitivity than ECG in response to ischemia,which may provide an alternative method for the diagnosis of ischemia. |
| Databáze: | OpenAIRE |
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