An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans
| Autor: | Adil, Mardinoglu, Hao, Wu, Elias, Bjornson, Cheng, Zhang, Antti, Hakkarainen, Sari M, Räsänen, Sunjae, Lee, Rosellina M, Mancina, Mattias, Bergentall, Kirsi H, Pietiläinen, Sanni, Söderlund, Niina, Matikainen, Marcus, Ståhlman, Per-Olof, Bergh, Martin, Adiels, Brian D, Piening, Marit, Granér, Nina, Lundbom, Kevin J, Williams, Stefano, Romeo, Jens, Nielsen, Michael, Snyder, Mathias, Uhlén, Göran, Bergström, Rosie, Perkins, Hanns-Ulrich, Marschall, Fredrik, Bäckhed, Marja-Riitta, Taskinen, Jan, Borén |
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| Přispěvatelé: | Clinicum, Department of Diagnostics and Therapeutics, HUS Medical Imaging Center, Diabetes and Obesity Research Program, Department of Medicine, Research Programs Unit, HUS Internal Medicine and Rehabilitation, HUS Abdominal Center, Kirsi Hannele Pietiläinen / Principal Investigator, Endokrinologian yksikkö, Marja-Riitta Taskinen Research Group, HUS Heart and Lung Center |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
INSULIN-RESISTANCE Cellbiologi GUT MICROBIOTA WEIGHT-LOSS Cell Biology Middle Aged Lipid Metabolism VERY-LOW-CARBOHYDRATE FOLATE-DEFICIENCY Article Gastrointestinal Microbiome GLUTATHIONE METABOLISM Cohort Studies Diet Carbohydrate-Restricted Folic Acid LIPID-METABOLISM Non-alcoholic Fatty Liver Disease PPAR-ALPHA 3121 General medicine internal medicine and other clinical medicine Humans 1182 Biochemistry cell and molecular biology Female NONALCOHOLIC FATTY LIVER GROWTH-FACTOR 21 |
| Popis: | A carbohydrate-restricted diet is a widely recommended intervention for non-alcoholic fatty liver disease (NAFLD), but a systematic perspective on the multiple benefits of this diet is lacking. Here, we performed a short-term intervention with an isocaloric low-carbohydrate diet with increased protein content in obese subjects with NAFLD and characterized the resulting alterations in metabolism and the gut microbiota using a multi-omics approach. We observed rapid and dramatic reductions of liver fat and other cardiometabolic risk factors paralleled by (1) marked decreases in hepatic de novo lipogenesis; (2) large increases in serum beta-hydroxybutyrate concentrations, reflecting increased mitochondrial beta-oxidation; and (3) rapid increases in folate-producing Streptococcus and serum folate concentrations. Liver transcriptomic analysis on biopsy samples from a second cohort revealed downregulation of the fatty acid synthesis pathway and upregulation of folate-mediated one-carbon metabolism and fatty acid oxidation pathways. Our results highlight the potential of exploring diet-microbiota interactions for treating NAFLD. QC 20180404 |
| Databáze: | OpenAIRE |
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