| Autor: |
L, Camba, L, Aldrighetti, F, Ciceri, M, Bernardi, S, Marktel, E, Angeli, M, Giacomelli |
| Přispěvatelé: |
Camba, L, Aldrighetti, L, Ciceri, Fabio, Bernardi, M, Marktel, S, Angeli, E, Giacomelli, M. |
| Rok vydání: |
2001 |
| Předmět: |
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| Popis: |
A 79-year-old patient with post-polycythaemic myelofibrosis presented with severe hypersplenism. After splenic artery catheterization, cytosine arabinoside was given intrasplenically from November 1999 to March 2000 for 5 d/month at 10 mg/m(2) and increased each month by 10 mg/m(2). It was then administered by continuous infusion until June 2000, starting at 20 mg/m(2)/d and tapering by 5 mg/m(2) every 2 weeks to a final daily dose of 5 mg/m(2)/d. The drug was then stopped. The spleen had decreased to one third of the initial volume. Clinical conditions and haematological indices improved substantially. Intrasplenic therapy could be a new therapeutic tool for hypersplenism in chronic idiopathic and post-myeloproliferative myelofibrosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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