Carbonylation accumulation of the Hypsibius exemplaris anhydrobiote reveals age-associated marks
| Autor: | Kuzmic, M., Richaud, M., Cuq, P., Frelon, S., Galas, S. |
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| Přispěvatelé: | PSE-ENV/SRTE, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Centre National de la Recherche Scientifique, CNRS |
| Rok vydání: | 2018 |
| Předmět: |
Ultraviolet radiation
Embryology Atmospheric Science Time Factors Light Ultraviolet Rays Imaging Techniques [SDV]Life Sciences [q-bio] Science Pathology and Laboratory Medicine Research and Analysis Methods Biochemistry Extremophiles Oxidative Damage Signs and Symptoms Meteorology Fluorescence Microscopy Electromagnetic radiation Diagnostic Medicine Fluorescence Imaging Tardigrada Medicine and Health Sciences Animals Dehydration (Medicine) Aldehydes Microscopy Microscopy Confocal Physics fungi Ecology and Environmental Sciences Embryos food and beverages Biology and Life Sciences Light Microscopy Humidity Ketones Physical sciences Earth Sciences Medicine Ultraviolet C Reactive Oxygen Species Research Article Developmental Biology |
| Zdroj: | PLoS ONE PLoS ONE, Vol 13, Iss 12, p e0208617 (2018) PLoS ONE, Public Library of Science, 2018, 13 (12), pp.e0208617. ⟨10.1371/journal.pone.0208617⟩ |
| ISSN: | 1932-6203 |
| Popis: | International audience; Together with nematodes and rotifers, tardigrade belong to micrometazoans that can cope with environmental extremes such as UV and solar radiations, dehydration, supercooling or overheating. Tardigrade can resist the harshest conditions by turning to cryptobiosis, an anhydrobiotic state that results from almost complete dehydration and is characterized by an ametabolic status. Although reports have challenged the molecular basis of the mechanisms underlying genomic injury resistance, little is yet known regarding the possible involvement of other tardigrade macromolecules in injury during a stress experience. In this report, we show that the tardigrade Hypsibius exemplaris can accumulate molecular damages by means of in situ detection of carbonyls. Furthermore, we demonstrate that living tardigrade can accumulate carbonylation. Finally, we reveal that anhydrobiotic tardigrade can be constitutively affected by carbonylation that marks aging in other metazoans. © 2018 Kuzmic et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Databáze: | OpenAIRE |
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