Protective effects of thymoquinone and alpha-tocopherol on the sciatic nerve and femoral muscle due to lower limb ischemia-reperfusion injury

Autor:	Erkan CÜRE, Cure, M. C., Kalkan, Y., Balik, M. S., Guvercin, Y., Yaprak, E., Yuce, S., Sehitoglu, I., Cure, E.
Přispěvatelé:	RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Erkut, Adem, Cüre, Medine Cumhur, Kalkan, Yıldıray, Balık, Mehmet Sabri, Güvercin, Yılmaz, Yaprak, Esra, Şehitoğlu, İbrahim, Cüre, Erkan
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Male Muscles Ischemia-reperfusion alpha-Tocopherol Sciatic nerve Sciatic Nerve Antioxidants Rats Lower Extremity Reperfusion Injury Benzoquinones Animals Alpha-tocopherol Vitamin E Muscle Nigella sativa Rats Wistar Thymoquinone
Zdroj:	Europe PubMed Central ResearcherID Publons
Popis:	cure, erkan/0000-0001-7807-135X; Cure, Medine Cumhur/0000-0001-9253-6459 WOS: 000376901700031 PubMed: 27049277 OBJECTIVE: Thymoquinone (TQ) is an antioxidant and anti-apoptotic substance found in the Nigella sativa plant. Alpha-tocopherol (alpha-TP) is a potent antioxidant. We aimed to determine whether or not TQ and TP have a protective effect against lower limb ischemia-reperfusion (IR) injury of muscle and the sciatic nerve. MATERIALS AND METHODS: A single dose of TQ 25 mg/kg was given intraperitoneally to the TQ group, a single dose of alpha-TP 200 mg/kg was given intraperitoneally to the alpha-TP group. IR was performed for 45 minutes after the drugs' applications. RESULTS: While serum levels of malondialdehyde (MDA) and interleukin-6 (IL-6) of the IR group were significantly higher than those of the TQ plus alpha-TP, TQ and alpha-TP groups (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3039f7724b0c0464311dcc82188578c5 https://hdl.handle.net/11436/2561 Zobrazit plný text záznamu