3,5-Diphenyl-1H-pyrazole derivatives. XII. N-substituted 4-amino-1-(2-hydroxy- or 2-alkylaminoethyl)-3,5-diphenyl-1H-pyrazoles with local anesthetic, analgesic and platelet antiaggregating activities
| Autor: | Bruno, O., Ranise, A., Bondavalli, F., Schenone, S., michele d'amico, Falciani, M., Vacca, C., Filippelli, A. |
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| Přispěvatelé: | Bruno, O, Ranise, A, Bondavalli, F, Schenone, S, D'Amico, Michele, Falciani, M, Vacca, C, Filippelli, A. |
| Rok vydání: | 1994 |
| Předmět: |
Analgesics
Mice Local chemical synthesis/pharmacology Anesthetics chemical synthesis/pharmacology Animals Mice Platelet Aggregation Inhibitors chemical synthesis/pharmacology Pyrazoles chemical synthesis/pharmacology Rats chemical synthesis/pharmacology Animals Pyrazoles Anesthetics Local Platelet Aggregation Inhibitors Anesthetics Rats |
| Zdroj: | Scopus-Elsevier |
| Popis: | The synthesis of 4-amino-3,5-diphenyl-1H-pyrazole-1-ethanol, as well as of their N-methyl, N-ethyl and N,N-dimethyl derivatives is described. A series of 1-(2-alkylaminoethyl)-3,5-diphenyl-1H-pyrazole-4-amines and of N-substituted 4-dimethylamino-3,5-diphenyl-1H-pyrazole-1-ethanamines were also prepared. Some of the above compounds showed remarkable local anesthetic, analgesic and in vitro platelet antiaggregating activities, as well as moderate antiinflammatory and antipyretic activities in rats and mice. |
| Databáze: | OpenAIRE |
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