Comparison of iopamidol and ioversol in vitro and in animal studies
| Autor: | Werner Krause, Miyazawa T, Uchimoto R, Murayama C, Fritz-Zieroth B, Press Wr, Frenzel T |
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| Předmět: |
Male
Mice Inbred ICR Whole Blood Coagulation Time Chemical Phenomena Chemistry Physical Angiography Contrast Media In Vitro Techniques Motor Activity Iopamidol Rats Femoral Artery Mice Erythrocyte Deformability Triiodobenzoic Acids Animals Female Muramidase Rabbits Nervous System Diseases Rats Wistar |
| Zdroj: | The Lens |
| Popis: | In the present series of studies we investigated differences in vitro and in animal experiments between iopamidol (Iopamiron, CAS 60166-93-0) and ioversol (CAS 87771-40-2). The studies included the in vitro investigations partition coefficient, lysozyme inhibition, coagulation time and erythrocyte morphology as well as the in vivo paradigms acute toxicity, neural toxicity, general behavior/locomotor activity and angiography. Iopamidol was superior to ioversol in most of the tests. In spite of its higher hydrophilicity, ioversol did not show improved tolerance in comparison to iopamidol. |
| Databáze: | OpenAIRE |
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