Endotoxin shock in the rat: reduction of arterial blood pressure fall by the bradykinin antagonist B4148

Autor:	Weipert J, Hoffmann H, matthias siebeck, Et, Whalley
Rok vydání:	1989
Předmět:	Lipopolysaccharides Male Kinetics Escherichia coli Animals Rats Inbred Strains Hypotension Kallidin Bradykinin Shock Septic Rats
Zdroj:	Europe PubMed Central
ISSN:	0361-7742
Popis:	The selective competitive bradykinin (BK) antagonist (B4148) produced significant inhibition of the hypotensive effect of BK in rats. Using a rat model of endotoxin shock, the fall in mean arterial blood pressure to an intravenous injection of lipopolysaccharide from E. coli was significantly attenuated by the B4148 as compared to controls. These findings suggest that kinins are involved in the hypotensive response to endotoxin shock in rats. The development of potent BK antagonists offers a new experimental approach for evaluating the role of kinins in this and other disease states.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2f9110710df682bff7cf859b46db45d8 https://pubmed.ncbi.nlm.nih.gov/2675079 Zobrazit plný text záznamu