Age-independent increasing prevalence of Human Papillomavirus-driven oropharyngeal carcinomas in North-East Italy
| Autor: | Del Mistro, A., Frayle, H., Menegaldo, A., Favaretto, N., Gori, S., Nicolai, P., Spinato, G., Romeo, S., Tirelli, G., da Mosto, M. C., Polesel, J., Boscolo Rizzo, P., BOSCOLO RIZZO, Paolo |
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| Přispěvatelé: | Del Mistro, A., Frayle, H., Menegaldo, A., Favaretto, N., Gori, S., Nicolai, P., Spinato, G., Romeo, S., Tirelli, G., da Mosto, M. C., Polesel, J., Boscolo Rizzo, P., BOSCOLO RIZZO, Paolo |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male HPV Palatine Tonsil lcsh:Medicine papillomavirus Article Prognostic markers Age Distribution Medical research oropharyngeal carcinoma Prevalence Humans lcsh:Science Papillomaviridae Cyclin-Dependent Kinase Inhibitor p16 Aged Cancer Aged 80 and over Papillomavirus Infections lcsh:R virus diseases papillomaviru Diagnostic markers Middle Aged Viral Load female genital diseases and pregnancy complications Oropharyngeal Neoplasms Italy Female lcsh:Q |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Scientific Reports |
| Popis: | HPV-driven oropharyngeal carcinomas (OPCs) show geographical variations with increasing temporal trends in several areas. We investigated their frequency and clinical outcomes within a prospective multicenter cohort study in North-East Italy. A tumor was defined as HPV-driven by using at least two different biomarkers, usually HPV-DNA positivity and p16INK4A overexpression. Different survival outcomes were compared among patients with HPV-driven and non-HPV-driven tumors. Overall, 42/130 (32.3%) patients with newly diagnosed OPC during the period 2000–2018 resulted HPV-driven; HPV16 was involved in 37 cases (88%), HPV33 in 3 cases (7%), HPV58 and HPV18 in 1 case each. Over time, HPV-driven cases raised from 16.7% (6/36) during 2000–2006 to 46.1% (24/52) during 2013–2018 (p |
| Databáze: | OpenAIRE |
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