Burden of critically ill patients with influenza in a French catchment population
| Autor: | Romain Hernu, Marie Simon, Thomas Baudry, Jean-Sébastien Casalegno, Bruno Lina, Martin Cour, Laurent Argaud, the 'Flu in Lyon ICUs' Study Group |
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| Přispěvatelé: | CarMeN, laboratoire, Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Centre National de Référence des Virus des Infections Respiratoires (dont la Grippe) [Lyon] (CNR), Institut des Agents Infectieux [Lyon] (IAI), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), 'Flu in Lyon ICUs' Study Group: Frederic Aubrun, Claude Guérin, Bernard Allaouchiche, Dominique Robert, Julien Bohé, Marc Puidupin, Jacques Manchon, Lionel Liron. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Science Critical Illness [SDV]Life Sciences [q-bio] Diseases Article Cohort Studies Catchment Area Health Influenza Human Humans Prospective Studies Aged Bed Occupancy virus diseases Middle Aged [SDV] Life Sciences [q-bio] Influenza B virus Intensive Care Units Influenza A virus Medicine Infectious diseases Female France Seasons Influenza virus |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.10526. ⟨10.1038/s41598-021-89912-y⟩ Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021) |
| ISSN: | 2045-2322 |
| Popis: | International audience; Despite the particular focus given to influenza since the 2009 influenza A(H1N1) pandemic, true burden of influenza-associated critical illness remains poorly known. The aim of this study was to identify factors influencing influenza burden imposed on intensive care units (ICUs) in a catchment population during recent influenza seasons. From 2008 to 2013, all adult patients admitted with a laboratory-confirmed influenza infection to one of the ICUs in the catchment area were prospectively included. A total of 201 patients (mean age: 63 ± 16, sex-ratio: 1.1) were included. The influenza-related ICU-bed occupancy rate averaged 4.3% over the five influenza seasons, with the highest mean occupancy rate (16.9%) observed during the 2012 winter. In-hospital mortality for the whole cohort was 26%. Influenza A(H1N1)pdm infections (pdm in the mentioned nomenclature refers to Pandemic Disease Mexico 2009), encountered in 51% of cases, were significantly associated with neither longer length of stay nor higher mortality (ICU and hospital) when compared to infections with other virus subtypes. SOFA score (OR, 1.12; 95% CI, 1.04-1.29) was the only independent factor significantly associated with a prolonged hospitalization. These results highlight both the frequency and the severity of influenza-associated critical illness, leading to a sustained activity in ICUs. Severity of the disease, but not A(H1N1)pdm virus, appears to be a major determinant of ICU burden related to influenza. |
| Databáze: | OpenAIRE |
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