| Autor: |
Romeo, Giovanna, Fiorucci, G., Chiantore, M. V., Percario, Z. A., Vannucchi, S., Affabris, E. |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 22(1) |
| ISSN: |
1079-9907 |
| Popis: |
Numerous evidence has demonstrated the involvement in growth control of interferon (IFN) regulatory factor-1 (IRF-1), which shows tumor suppressor activity. IRF-1 is a well-studied member of the IRF transcription factors that reveals functional diversity in the regulation of cellular response by activating expression of a diverse set of target genes, depending on the cell type and on the specific stimuli. IRF-1 gene rearrangements may be a crucial point in the pathogenesis of some cancer types. Furthermore, different aspects of the tumor suppressor function of IRF-1 may be explained, at least in part, by the observations that IRF-1 is a regulator of cell cycle and apoptosis and that its inactivation accelerates cell transformation. Studies on gene knockout mice contributed greatly to the clarification of these multiple IRF-1 functions. We summarize our current knowledge of the antigrowth effect of IRF-1, focusing also on a more general involvement of IRF-1 in mediating negative regulation of cell growth induced by numerous cytokines and other biologic response modifiers. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
