Realistic simulation and experiment reveals the importance of scatterer microstructure in optical coherence tomography image formation

Autor: Ossowski, Pawel, Curatolo, A., Sampson, David D., Munro, Peter R. T.
Přispěvatelé: Royal Society (UK), Biotechnology and Biological Sciences Research Council (UK), National Science Centre (Poland), Australian Research Council
Rok vydání: 2018
Předmět:
Zdroj: Biomedical Optics Express
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
ISSN: 2156-7085
Popis: 15 pags., 12 figs. -- OCIS codes: (170.3660) Light propagation in tissues; (050.1755) Computational electromagnetic methods; (180.0180) Microscopy; (110.4500) Optical coherence tomography. -- Corrections: 20 June 2018: Typographical corrections were made to the funding section and acknowledgments.
Realistic simulation of image formation in optical coherence tomography, based on Maxwell’s equations, has recently been demonstrated for sample volumes of practical significance. Yet, there remains a limitation whereby reducing the size of cells used to construct a computational grid, thus allowing for more realistic representation of scatterer microstructure, necessarily reduces the overall sample size that can be modelled. This is a significant problem since, as is well known, the microstructure of a scatterer significantly influences its scattering properties. Here we demonstrate that optimized scatterer design can overcome this problem resulting in good agreement between simulated and experimental images for a structured phantom. This approach to OCT image simulation allows for image formation for biological tissues to be simulated with unprecedented realism.
P.M. is supported by a Royal Society University Research Fellowship. This work was partially supported by BBSRC grant BB/P027008/1. P.M. is also grateful to Christian Winter (Thorlabs) for providing information on the Thorlabs Telesto II and for helpful discussions on this information. P.O. acknowledges support from the National Science Center within the MAESTRO Programme (DEC-2011/02/A/ST2/00302). This work was partially supported by the Australian Research Council (D. S.)
Databáze: OpenAIRE
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