| Autor: |
Ronsisvalle, G., Pappalardo, M. S., Vittorio, F., Lorella Giuseppina Pasquinucci, Bousquet, E., Oliveri, S., Cammarata, E. |
| Rok vydání: |
1989 |
| Předmět: |
|
| Zdroj: |
Scopus-Elsevier |
| ISSN: |
0014-827X |
| Popis: |
Some pyrimidines, pyrazolo[3,4-d]pyrimidines and imidazo[4,5-d]pyrimidines bearing the 5-nitro- and 5-aminothienyl-2-sulfide functionalities on the pyrimidine nucleus were synthesized and evaluated for their antifungal activity against several strains of yeasts and dermatophytes. 4-Amino-2-pyrimidinyl-5'-nitro-2'-thienylsulfide (Va) resulted active against both yeasts and dermatophytes (about 30 fold less potent than Miconazole). Compds. (II b), (V b) and (VIII b) showed only a slight activity against dermatophytes, while the other compounds were inactive. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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