Inhibitors of lipid peroxidation among new pyrimido[1',6':1,2]pyrido[3,4-b]indoles
Autor: | Domany, G., Gere, A., Paroczai, M., Szantay Jr, C. S., György Ferenczy, Schon, I., Kiss, B., Karpati, E. |
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Rok vydání: | 1994 |
Předmět: | |
Zdroj: | Europe PubMed Central Scopus-Elsevier |
ISSN: | 0031-7144 |
Popis: | A series of potent inhibitors of NADPH- and Fe(2+)-dependent lipid peroxidation has been found among new pyrimido[1'6':1,2]pyrido[3,4-b]indole derivatives. According to preliminary structure-activity relationship analysis the saturated pyrimidine moiety was responsible for this effect. Some members of this family were effective in a bilateral carotid occlusion model in mice, and some derivatives showed protective effect in a mouse head injury model. |
Databáze: | OpenAIRE |
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