Inhibitors of lipid peroxidation among new pyrimido[1',6':1,2]pyrido[3,4-b]indoles

Autor: Domany, G., Gere, A., Paroczai, M., Szantay Jr, C. S., György Ferenczy, Schon, I., Kiss, B., Karpati, E.
Rok vydání: 1994
Předmět:
Zdroj: Europe PubMed Central
Scopus-Elsevier
ISSN: 0031-7144
Popis: A series of potent inhibitors of NADPH- and Fe(2+)-dependent lipid peroxidation has been found among new pyrimido[1'6':1,2]pyrido[3,4-b]indole derivatives. According to preliminary structure-activity relationship analysis the saturated pyrimidine moiety was responsible for this effect. Some members of this family were effective in a bilateral carotid occlusion model in mice, and some derivatives showed protective effect in a mouse head injury model.
Databáze: OpenAIRE