| Autor: |
McGuffin, P, Sargeant, M, Hetti, G, Tidmarsh, S, Whatley, S, Marchbanks, R M |
| Rok vydání: |
1990 |
| Předmět: |
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| Zdroj: |
American journal of human genetics. 47(3) |
| ISSN: |
0002-9297 |
| Popis: |
The report of a putative schizophrenia susceptibility gene linked to markers in the chromosome 5q11-q13 region and subsequent failures of replication have provoked considerable controversy. We here report six Welsh families multiply affected with schizophrenia in which there is no evidence for linkage between a dominant-like schizophrenia gene and 5q11-q13 markers. It is argued that our new results together with a combined reanalysis of previous studies suggest that a schizophrenia susceptibility gene can be excluded from the 5q11-q13 region. The apparent disparities between published results are most likely to reflect a chance finding in the one positive study and probably should not be interpreted as resulting from true linkage heterogeneity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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