Energy and macronutrient intake and risk of differentiated thyroid carcinoma in the European Prospective Investigation into Cancer and Nutrition study
Autor: | Raul, Zamora-Ros, Sabina, Rinaldi, Konstantinos K, Tsilidis, Elisabete, Weiderpass, Marie-Christine, Boutron-Ruault, Agnetha Linn, Rostgaard-Hansen, Anne, Tjønneland, Françoise, Clavel-Chapelon, Sylvie, Mesrine, Verena A, Katzke, Tilman, Kühn, Jana, Förster, Heiner, Boeing, Antonia, Trichopoulou, Pagona, Lagiou, Eleni, Klinaki, Giovanna, Masala, Sabina, Sieri, Fulvio, Ricceri, Rosario, Tumino, Amalia, Mattiello, Petra H M, Peeters, H B As, Bueno-de-Mesquita, Dagrun, Engeset, Guri, Skeie, Marcial, Argüelles, Antonio, Agudo, María-José, Sánchez, María-Dolores, Chirlaque, Aurelio, Barricarte, Saioa, Chamosa, Martin, Almquist, Ada, Tosovic, Joakim, Hennings, Maria, Sandström, Julie A, Schmidt, Kay-Thee, Khaw, Nicholas J, Wareham, Amanda J, Cross, Nadia, Slimani, Graham, Byrnes, Isabelle, Romieu, Elio, Riboli, Silvia, Franceschi |
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Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
Adult
Male Cancer Research macronutrients Article POOLED ANALYSIS Risk Factors Journal Article Odds Ratio Humans LOAD Oncology & Carcinogenesis Prospective Studies Thyroid Neoplasms differentiated thyroid carcinomas EPIC glycemic index total energy Aged Carcinoma Europe Female Glycemic Index Middle Aged Neoplasm Grading Diet Energy Intake METAANALYSIS POPULATION Science & Technology RECALLS CONSUMPTION Multicenter Study DIETARY PATTERNS Oncology OBESITY FATTY-ACIDS Life Sciences & Biomedicine 1112 Oncology And Carcinogenesis |
Zdroj: | International Journal of Cancer, 138(1), 65. Wiley-Liss Inc. |
ISSN: | 0020-7136 |
Popis: | Incidence rates of differentiated thyroid carcinoma (TC) have increased in many countries. Adiposity and dietary risk factors may play a role, but little is known on the influence of energy intake and macronutrient composition. The aim of this study was to investigate the associations between TC and the intake of energy, macronutrients, glycemic index (GI) and glycemic load in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 477,274 middle-age participants (70.2% women) from ten European countries. Dietary data were collected using country-specific validated dietary questionnaires. Total carbohydrates, proteins, fats, saturated, monounsaturated and polyunsaturated fats (PUFA), starch, sugar, and fiber were computed as g/1,000 kcal. Multivariable Cox regression was used to calculate multivariable adjusted hazard ratios (HR) and 95% confidence interval (CI) by intake quartile (Q). After a mean follow-up time of 11 years, differentiated TC was diagnosed in 556 participants (90% women). Overall, we found significant associations only with total energy (HRQ4 vs .Q1, 1.29; 95% CI, 1.00-1.68) and PUFA intakes (HRQ4 vs .Q1, 0.74; 95% CI, 0.57-0.95). However, the associations with starch and sugar intake and GI were significantly heterogeneous across body mass index (BMI) groups, i.e., positive associations with starch and GI were found in participants with a BMI≥25 and with sugar intake in those with BMI |
Databáze: | OpenAIRE |
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