Prevalence of M. tuberculosis infection and tuberculosis disease among HIV-infected people in Spain
| Autor: | Diez, M., Diaz, A., Bleda, M. J., Aldamiz, M., Camafort, M., Camino, X., Concepción Cepeda, Costa, A., Ferrero, O., Geijo, P., Iribarren, J. A., Moreno, S., Moreno, M. E., Labarga, P., Pinilla, J., Portu, J., Pulido, F., Rosa, C., Santamaria, J. M., Telenti, M., Trapiella, L., Trastoy, M., Viciana, R. |
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| Zdroj: | Scopus-Elsevier Europe PubMed Central ResearcherID |
| Popis: | To study the prevalence of Mycobacterium tuberculosis infection (MTBI) and past/current tuberculosis (TB) among human immunodeficiency virus (HIV) infected persons in Spain.Longitudinal study conducted between 2000 and 2003 at 10 HIV hospital-based clinics. Data were drawn from clinical records. Associations were measured using odds ratios (ORs) and their 95% confidence intervals (95%CI).Of the 1242 persons who met the eligibility criteria, most were male (75%), aged40 years (75%) and unemployed (40%). HIV infection occurred through intravenous drug use (53%), heterosexual sex (29%) and sex between men (16%). In the initial evaluation, 315 subjects had evidence of MTBI: 84 (6.8%) had a history of TB, 23 (1.8%) current TB and 208 (16.8%) latent tuberculosis infection (LTBI). MTBI was associated with male sex, age 30-49 years, contact with a TB case, homelessness, poor education, and negatively with CD4100 cells/mm(3). Among subjects with MTBI, past/current TB was associated with retirement/disability (OR 6, 95%CI 1.6-22.5), CD4200 cells/mm(3) (OR 9.7, 95%CI 3.8-24.6), viral load55,000 copies (OR 5.3, 95%CI 1.4-20.0), and negatively, with skilled work (OR 0.4, 95%CI 0.1-1.0) or administrative/managerial/professional work (OR 0.05, 95%CI 0.01-0.4).Social context has an impact on the effectiveness of HIV and TB control programmes even in industrialised countries with free access to health care. |
| Databáze: | OpenAIRE |
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