Sleep apnea and incident unprovoked venous thromboembolism: data from the Pays de la Loire sleep cohort
| Autor: | Wojciech, Trzepizur, Chloe, Gerves, Baptiste, Heudes, Margaux, Blanchard, Nicole, Meslier, Marie, Jouvenot, Sandrine, Kerbrat, Raphael, Le Mao, Eline, Magois, Jean Louis, Racineux, AbdelKebir, Sabil, Jeremie, Thereaux, Francis, Couturaud, Gagnadoux, Frederic |
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| Přispěvatelé: | Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Institut de Recherche en Santé Respiratoire Pays de la Loire (IRSR PL), École supérieure d'électronique de l'ouest [Angers] (ESEO), Centre Hospitalier Le Mans (CH Le Mans), Université de Rennes (UR), Recherche en Pharmaco-épidémiologie et Recours aux Soins (REPERES), Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP), CIC Brest, Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Cavale Blanche, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Pôle Santé des Olonnes, Cloud Sleep Lab |
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Thrombosis and Haemostasis Thrombosis and Haemostasis, 2023, ⟨10.1055/a-2000-8288⟩ |
| ISSN: | 0340-6245 |
| Popis: | International audience; BACKGROUND: Previous studies have reported inconsistent findings regarding the association between obstructive sleep apnea (OSA) and incident venous thromboembolism (VTE). More specifically, the association between OSA and unprovoked VTE was barely evaluated. We aimed to evaluate whether apnea hypopnea index (AHI) and nocturnal hypoxemia markers were associated with unprovoked VTE incidence in patients investigated for OSA. STUDY DESIGN AND METHODS: Data from the Pays de la Loire sleep cohort were linked to the French health administrative data to identify incident unprovoked VTE in patients suspected for OSA and no previous VTE disease. Cox proportional hazards models were used to evaluate the association of unprovoked VTE incidence with AHI and nocturnal hypoxemia markers including the time spend under 90% of saturation (T90), oxygen desaturation index and hypoxic burden (HB), a more specific marker of respiratory events related hypoxia. The impact of Continuous positive airway pressure (CPAP) was evaluated in the subgroup of patients who were proposed the treatment. RESULTS: After a median [inter-quartile range] follow-up of 6.3 [4.3-9.0] years, 104 of 7,355 patients developed unprovoked VTE, for an incidence rate of 10.8 per 1,000 patient-year. In a univariate analysis, T90 and HB predicted incident VTE. In the fully adjusted model, T90 was the only independent predictor (HR 1.06; 95%CI [1.01-1.02]; p=0.02). The CPAP treatment has no significant impact on VTE incidence. INTERPRETATION: Patients with more severe nocturnal hypoxia are more likely to have incident unprovoked VTE. |
| Databáze: | OpenAIRE |
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