Neonatal high protein intake enhances neonatal growth without significant adverse renal effects in spontaneous IUGR piglets

Autor: Boubred, Farid, Jamin, Agnès, Buffat, Christophe, Daniel, Laurent, Borel, Patrick, Boudry, Gaëlle, Luron, Isabelle, Simeoni, Umberto
Přispěvatelé: Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Laboratoire de biologie moléculaire, Université M'Hamed Bougara Boumerdes (UMBB), Laboratoire de Biopathologie de l'Adhésion et de la Signalisation (EA3281), Université de la Méditerranée - Aix-Marseille 2, DOHaD Laboratory CHUV, Lausanne University Hospital, Université de Lausanne, ANR grant # 05 PNRA‐009, Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université M'hamed Bougara, Institut National de la Recherche Agronomique (INRA)-Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lausanne = University of Lausanne (UNIL), ProdInra, Archive Ouverte
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
intrauterine growth restriction
nephron number
Swine
animal diseases
Kidney Glomerulus
glomerular sclerosis
hypertrophie
Kidney
urologic and male genital diseases
lcsh:Physiology
sclérose
Animals
Animals
Newborn
Birth Weight
Diet
High-Protein/adverse effects
Dietary Proteins/administration & dosage
Female
Fetal Growth Retardation/diet therapy
Fetal Growth Retardation/pathology
Fetal Growth Retardation/physiopathology
Kidney/anatomy & histology
Kidney/physiology
Kidney Glomerulus/anatomy & histology
Organ Size
Catch‐up growth
high protein intake
low birth weight
sclerosis
health services administration
filtration glomérulaire
glomerular filtration
Food and Nutrition
alimentation neonatale
ComputingMilieux_MISCELLANEOUS
Original Research
Fetal Growth Retardation
lcsh:QP1-981
protein content
female genital diseases and pregnancy complications
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition
teneur en protéines
Alimentation et Nutrition
Diet
High-Protein
retard de croissance intrautérine
protéine tissulaire
Dietary Proteins
hypertrophy
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
développement néonatal
Zdroj: Physiological Reports
Physiological Reports, Wiley, 2017, 5 (10), pp.e13296. ⟨10.14814/phy2.13296⟩
Physiological Reports 10 (5), . (2017)
Physiological Reports, 2017, 5 (10), pp.e13296. ⟨10.14814/phy2.13296⟩
Physiological Reports, Vol 5, Iss 10, Pp n/a-n/a (2017)
Physiological reports, vol. 5, no. 10, pp. e13296
ISSN: 2051-817X
DOI: 10.14814/phy2.13296⟩
Popis: In humans, early high protein (HP) intake has been recommended to prevent postnatal growth restriction and complications of intrauterine growth restriction (IUGR). However, the impact of such a strategy on the kidneys remains unknown, while significant renal hypertrophy, proteinuria, and glomerular sclerosis have been demonstrated in few experimental studies. The objective of this study was to evaluate the effects of a neonatal HP formula on renal structure in IUGR piglets. Spontaneous IUGR piglets were randomly allocated to normal protein (NP, javax.xml.bind.JAXBElement@68d5845e = 10) formula or to HP formula (+50% protein content, javax.xml.bind.JAXBElement@3e768c15 = 10) up to day 28 after birth. Body weight, body composition, renal functions, and structure were assessed at the end of the neonatal period. While birth weights were similar, 28-day-old HP piglets were 18% heavier than NP piglets ( javax.xml.bind.JAXBElement@206b72ec < javax.xml.bind.JAXBElement@7f241a6d 0.01). Carcass protein content was 22% higher in HP than in NP offspring ( javax.xml.bind.JAXBElement@3b9786a3 < javax.xml.bind.JAXBElement@318ba3e0 0.01). Despite a HP intake, kidney weight and glomerular fibrosis were unaltered in HP piglets. Only a 20% increase in glomerular volume was noted in HP piglets ( javax.xml.bind.JAXBElement@4a0c5b2f
Databáze: OpenAIRE
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