The Molecular Registry of Pituitary Adenomas (REMAH): A bet of Spanish Endocrinology for the future of individualized medicine and translational research
| Autor: | Raúl M, Luque, Alejandro, Ibáñez-Costa, Laura, Sánchez-Tejada, Esther, Rivero-Cortés, Mercedes, Robledo, Ainara, Madrazo-Atutxa, Mireia, Mora, Clara V, Álvarez, Tomás, Lucas-Morante, Cristina, Álvarez-Escolá, Carmen, Fajardo, Luis, Castaño, Sonia, Gaztambide, Eva, Venegas-Moreno, Alfonso, Soto-Moreno, María Ángeles, Gálvez, Javier, Salvador, Elena, Valassi, Susan M, Webb, Antonio, Picó, Manel, Puig-Domingo, Montserrat, Gilabert, Ignacio, Bernabéu, Mónica, Marazuela, Alfonso, Leal-Cerro, Justo P, Castaño |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adenoma
Adult Male Adolescent Databases Factual Real-Time Polymerase Chain Reaction Translational Research Biomedical Young Adult Endocrinology Humans Pituitary Neoplasms RNA Neoplasm Receptors Pituitary Hormone Registries Precision Medicine Child Molecular Biology Genetic Association Studies Societies Medical Aged Tumor Gene Expression Profiling Middle Aged Pituitary adenoma Multicenter study Neoplasm Proteins Pituitary Hormones Cushing Spain Acromegaly Female |
| Zdroj: | Endocrinologia y Nutricion r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 1575-0922 |
| Popis: | Pituitary adenomas are uncommon, difficult to diagnose tumors whose heterogeneity and low incidence complicate large-scale studies. The Molecular Registry of Pituitary Adenomas (REMAH) was promoted by the Andalusian Society of Endocrinology and Nutrition (SAEN) in 2008 as a cooperative clinical-basic multicenter strategy aimed at improving diagnosis and treatment of pituitary adenomas by combining clinical, pathological, and molecular information. In 2010, the Spanish Society of Endocrinology and Nutrition (SEEN) extended this project to national level and established 6 nodes with common protocols and methods for sample and clinical data collection, molecular analysis, and data recording in a common registry (www.remahnacional.com). The registry combines clinical data with molecular phenotyping of the resected pituitary adenoma using quantitative real-time PCR of expression of 26 genes: Pituitary hormones (GH-PRL-LH-FSH-PRL-ACTH-CGA), receptors (somatostatin, dopamine, GHRH, GnRH, CRH, arginine-vasopressin, ghrelin), other markers (Ki67, PTTG1), and control genes. Until 2015, molecular information has been collected from 704 adenomas, out of 1179 patients registered. This strategy allows for comparative and relational analysis between the molecular profile of the different types of adenoma and the clinical phenotype of patients, which may provide a better understanding of the condition and potentially help in treatment selection. The REMAH is therefore a unique multicenter, interdisciplinary network founded on a shared database that provides a far-reaching translational approach for management of pituitary adenomas, and paves the way for the conduct of combined clinical-basic innovative studies on large patient samples. (C) 2016 SEEN. Published by Elsevier Espana, S.L.U. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|