Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors

Autor: Rudolph, A., Milne, R. L., Truong, T., Knight, J. A., Seibold, P., Flesch-Janys, D., Behrens, S., Eilber, U., Bolla, M. K., Wang, Q., Dennis, J., Dunning, A. M., Shah, M., Munday, H. R., Darabi, H., Eriksson, M., Brand, J. S., Olson, J., Vachon, C. M., Hallberg, E., Castelao, J. E., Carracedo, A., Torres, M., Li, J., Humphreys, K., Cordina-Duverger, E., Menegaux, F., Flyger, H., Nordestgaard, B. G., Nielsen, S. F., Yesilyurt, B. T., Floris, G., Leunen, K., Engelhardt, E. G., Broeks, A., Rutgers, E. J., Glendon, G., Mulligan, A. M., Cross, S., Reed, M., Gonzalez-Neira, A., Perez, J. I. A., Provenzano, E., Apicella, C., Southey, M. C., Spurdle, A., Häberle, L., Beckmann, M. W., Ekici, A. B., Dieffenbach, A. K., Arndt, V., Stegmaier, C., McLean, C., Baglietto, L., Chanock, S. J., Lissowska, J., Sherman, M. E., Brüning, T., Hamann, U., Ko, Y. D., Orr, N., Schoemaker, M., Ashworth, A., Kosma, V. M., Kataja, V., Hartikainen, J. M., Mannermaa, A., Swerdlow, A., Giles, G. G., Brenner, H., Fasching, P. A., Chenevix-Trench, G., Hopper, J., Benítez, J., Cox, A., Andrulis, I. L., Lambrechts, D., Gago-Dominguez, M., Couch, F., Czene, K., Bojesen, S. E., Easton, D. F., Schmidt, M. K., Guénel, P., Hall, P., Pharoah, P. D. P., Garcia-Closas, M., Chang-Claude, J.
Přispěvatelé: Other departments
Rok vydání: 2014
Předmět:
Zdroj: International journal of cancer. Journal international du cancer, 136(6), E685-E696. Wiley-Liss Inc.
RUNA. Repositorio da Consellería de Sanidade e Sergas
Servizo Galego de Saúde (SERGAS)
ISSN: 1097-0215
0020-7136
Popis: A large genotyping project within the Breast Cancer Association Consortium (BCAC) recently identified 41 associations between single nucleotide polymorphisms (SNPs) and overall breast cancer (BC) risk. We investigated whether the effects of these 41 SNPs, as well as six SNPs associated with estrogen receptor (ER) negative BC risk are modified by 13 environmental risk factors for BC. Data from 22 studies participating in BCAC were pooled, comprising up to 26,633 cases and 30,119 controls. Interactions between SNPs and environmental factors were evaluated using an empirical Bayes-type shrinkage estimator. Six SNPs showed interactions with associated p-values (p(int))
Databáze: OpenAIRE
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