Exposure to Atmospheric Ultrafine Particles Induces Severe Lung Inflammatory Response and Tissue Remodeling in Mice
| Autor: | Saleh, Yara, Antherieu, Sebastien, Dusautoir, Romain, Y. Alleman, Laurent, Sotty, Jules, De Sousa, Corentin, Platel, Anne, Perdrix, Esperanza, Riffault, Véronique, Fronval, Isabelle, Nesslany, Fabrice, Canivet, Ludivine, Garçon, Guillaume, Lo-Guidice, Jean-Marc |
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| Přispěvatelé: | Impact de l'environnement chimique sur la santé humaine - ULR 4483 (IMPECS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP), Centre for Energy and Environment (CERI EE), Ecole nationale supérieure Mines-Télécom Lille Douai (IMT Lille Douai), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Institut Mines-Télécom [Paris] (IMT), This work was supported by the French Ministère de l’Enseignement Supérieur et de la Recherche, the Hauts de France Region and the European Funds for Regional Economical Development (CPER CLIMIBIO), and the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) (NANATMOPATH—N°2014-1-183). YS received a PhD fellowship funded by Lille University., We acknowledge Pascal Quentin from Oncovet Clinical Research for the histological analysis. IMT Lille Douai acknowledges financial support from the CaPPA project, which is funded by the French National Research Agency (ANR) through the PIA (Programme d’Investissement d’Avenir) under contract ANR-11-LABX-0005-01, the Regional Council 'Hauts-de-France' and the European Regional Development Fund (ERDF)., Centre for Energy and Environment (CERI EE - IMT Nord Europe), Ecole nationale supérieure Mines-Télécom Lille Douai (IMT Nord Europe), Foie, métabolismes et cancer, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Mines de Douai (Mines Douai EMD), Département S.A.G.E (SAGE), Impact de l'environnement chimique sur la santé humaine (IMPECS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
MESH: Systemic Inflammatory Response Syndrome/chemically induced Time Factors mice MESH: Mice Inbred BALB C lcsh:Medicine lung tissue remodeling MESH: Lung/drug effects Article MESH: Environmental Exposure/adverse effects MESH: Lung/immunology Animals MESH: Animals MESH: Particle Size Particle Size MESH: Mice Lung ComputingMilieux_MISCELLANEOUS Air Pollutants Mice Inbred BALB C MESH: Air Pollutants/adverse effects MESH: Air Pollutants/analysis MESH: Particulate Matter/administration & dosage MESH: Time Factors lcsh:R MESH: Particulate Matter/adverse effects Environmental Exposure MESH: Lung/pathology MESH: Male Systemic Inflammatory Response Syndrome Disease Models Animal Ultrafine particles inflammation [SDV.TOX]Life Sciences [q-bio]/Toxicology MESH: Environmental Exposure/analysis MESH: Systemic Inflammatory Response Syndrome/pathology Particulate Matter MESH: Disease Models Animal (sub)chronic exposure |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 16, Iss 7, p 1210 (2019) International Journal of Environmental Research and Public Health Volume 16 Issue 7 International Journal of Environmental Research and Public Health, MDPI, 2019, 16 (7), pp.1210. ⟨10.3390/ijerph16071210⟩ International Journal of Environmental Research and Public Health, 2019, 16 (7), pp.1210. ⟨10.3390/ijerph16071210⟩ |
| ISSN: | 1660-4601 1661-7827 |
| Popis: | Exposure to particulate matter (PM) is leading to various respiratory health outcomes. Compared to coarse and fine particles, less is known about the effects of chronic exposure to ultrafine particles, despite their higher number and reactivity. In the present study, we performed a time-course experiment in mice to better analyze the lung impact of atmospheric ultrafine particles, with regard to the effects induced by fine particles collected on the same site. Trace element and PAH analysis demonstrated the almost similar chemical composition of both particle fractions. Mice were exposed intranasally to FF or UFP according to acute (10, 50 or 100 µ g of PM) and repeated (10 µ g of PM 3 times a week during 1 or 3 months) exposure protocols. More particle-laden macrophages and even greater chronic inflammation were observed in the UFP-exposed mice lungs. Histological analyses revealed that about 50% of lung tissues were damaged in mice exposed to UFP for three months versus only 35% in FF-exposed mice. These injuries were characterized by alveolar wall thickening, macrophage infiltrations, and cystic lesions. Taken together, these results strongly motivate the update of current regulations regarding ambient PM concentrations to include UFP and limit their emission. |
| Databáze: | OpenAIRE |
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