Identifying redundant and missing relations in the Gene Ontology
| Autor: | Mougin, Fleur |
|---|---|
| Přispěvatelé: | Mougin, Fleur, Centre INSERM U897-Epidemiologie-Biostatistique (ISPED), Université de Bordeaux (UB) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
MESH: Gene Ontology
[INFO.INFO-AI] Computer Science [cs]/Artificial Intelligence [cs.AI] MESH: Terminology as Topic MESH: Vocabulary Controlled Quality Improvement MESH: Genes Data Accuracy Pattern Recognition Automated [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI] MESH: Natural Language Processing MESH: Quality Improvement Gene Ontology Genes Vocabulary Controlled Terminology as Topic MESH: Data Accuracy MESH: Pattern Recognition Automated ComputingMilieux_MISCELLANEOUS Natural Language Processing |
| Zdroj: | Studies in Health Technology and Informatics Studies in Health Technology and Informatics, IOS Press, 2015, 210, pp.195-9 Medical Informatics Europe Medical Informatics Europe, May 2015, Madrid, Spain. pp.195-199 |
| ISSN: | 0926-9630 1879-8365 |
| Popis: | International audience; Significant efforts have been undertaken for providing the Gene Ontology (GO) in a computable format as well as for enriching it with logical definitions. Automated approaches can thus be applied to GO for assisting its maintenance and for checking its internal coherence. However, inconsistencies may still remain within GO. In this frame, the objective of this work was to audit GO relationships. First, reasoning over relationships was exploited for detecting redundant relations existing between GO concepts. Missing necessary and sufficient conditions were then identified based on the compositional structure of the preferred names of GO concepts. More than one thousand redundant relations and 500 missing necessary and sufficient conditions were found. The proposed approach was thus successful for detecting inconsistencies within GO relations. The application of lexical approaches as well as the exploitation of synonyms and textual definitions could be useful for identifying additional necessary and sufficient conditions. Multiple necessary and sufficient conditions for a given GO concept may be indicative of inconsistencies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|