Prognostic values of tumor necrosis factor/cachectin, interleukin-1, interferon-alpha, and interferon-gamma in the serum of patients with septic shock. Swiss-Dutch J5 Immunoglobulin Study Group
| Autor: | Calandra, T., Baumgartner, J. D., Grau, G. E., Wu, M. M., Lambert, P. H., Schellekens, J., Verhoef, J., Glauser, M. P. |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Analysis of Variance Adolescent Tumor Necrosis Factor-alpha Middle Aged Prognosis Shock Septic Interferon-gamma Random Allocation Adolescent Adult Aged Analysis of Variance Child Double-Blind Method Female Humans Interferon Type I/*blood Interferon Type II/*blood Interleukin-1/*analysis Male Middle Aged Prognosis Prospective Studies Random Allocation Regression Analysis Shock Septic/*diagnosis Tumor Necrosis Factor-alpha/*analysis Double-Blind Method Interferon Type I Humans Regression Analysis Female Prospective Studies Child Aged Interleukin-1 |
| Zdroj: | Journal of Infectious Diseases, vol. 161, no. 5, pp. 982-7 |
| ISSN: | 0022-1899 |
| Popis: | Serum concentrations of immunoreactive tumor necrosis factor/cachectin (TNF), interleukin-1 beta (IL-1 beta), interferon-gamma (IFN gamma), and interferon-alpha (IFN alpha) were prospectively measured in 70 patients with septic shock to determine their evolution and prognostic values. In a univariate analysis, levels of TNF (P = .002) and IL-1 beta (P = .05) were associated with the patient's outcome, but not IFN alpha (P = .15) and IFN gamma (P = .26). In contrast, in a stepwise logistic regression analysis, the severity of the underlying disease (P = .01), the age of the patient (P = .02), the documentation of infection (nonbacteremic infections vs. bacteremias, P = .03), the urine output (P = .04), and the arterial pH (P = .05) contributed more significantly to prediction of patient outcome than the serum levels of TNF (P = .07). After 10 days, the median concentration of TNF was undetectable (less than 100 pg/ml) in the survivors, whereas it remained elevated (305 pg/ml, P = .002) in the nonsurvivors. Thus, in patients with septic shock due to various gram-negative bacteria, other parameters than the absolute serum concentration of immunoreactive TNF contributed significantly to the prediction of outcome. |
| Databáze: | OpenAIRE |
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