Robust innate responses to SARS-CoV-2 in children resolve faster than in adults without compromising adaptive immunity

Autor: Vono, Maria, Huttner, Angela, Lemeille, Sylvain, Martinez-Murillo, Paola, Meyer, Benjamin, Baggio, Stephanie, Sharma, Shilpee, Thiriard, Anais, Marchant, Arnaud, Godeke, Gert-Jan, Reusken, Chantal, Alvarez, Catia, Perez-Rodriguez, Francisco, Eckerle, Isabella, Kaiser, Laurent, Loevy, Natasha, Eberhardt, Christiane S., Blanchard-Rohner, Geraldine, Siegrist, Claire-Anne, Didierlaurent, Arnaud M.
Jazyk: angličtina
Rok vydání: 2021
Předmět:
COVID-19 / virology
COVID-19 / genetics
Monocytes / metabolism
ddc:616.07
Adaptive Immunity
Antibodies
Viral
Monocytes
Gene profile
antibodies
Inflammation / virology
Longitudinal Studies
Biology (General)
Child
Children
Innate responses
ddc:616
B-Lymphocytes
ddc:618
interferon
Middle Aged
Viral Load
innate responses
Child
Preschool
Cytokines
Interferon
Adult
Adolescent
QH301-705.5
Sciences de l'ingénieur
IFN
Article
Antibodies
Granulocyte-Macrophage Colony-Stimulating Factor / metabolism
Young Adult
children
COVID-19 / immunology
Chemokine CXCL10 / metabolism
Humans
ddc:613
Inflammation
B cells
SARS-CoV-2
Sequence Analysis
RNA
DC activation
Granulocyte-Macrophage Colony-Stimulating Factor
resolution
COVID-19
Infant
Interferons / metabolism
B-Lymphocytes / metabolism
gene profile
Immunity
Innate
Chemokine CXCL10
Cytokines / metabolism
Antibodies
Viral / immunology
Interferons
Resolution
Transcriptome
SARS-CoV-2 / immunology
Zdroj: Cell reports, Vol. 37, No 1 (2021) P. 109773
Cell Reports
Cell Reports, Vol 37, Iss 1, Pp 109773-(2021)
Cell reports, 37 (1
ISSN: 2211-1247
Popis: SARS-CoV-2 infection in children is less severe than it is in adults. We perform a longitudinal analysis of the early innate responses in children and adults with mild infection within household clusters. Children display fewer symptoms than adults do, despite similar initial viral load, and mount a robust anti-viral immune signature typical of the SARS-CoV-2 infection and characterized by early interferon gene responses; increases in cytokines, such as CXCL10 and GM-CSF; and changes in blood cell numbers. When compared with adults, the antiviral response resolves faster (within a week of symptoms), monocytes and dendritic cells are more transiently activated, and genes associated with B cell activation appear earlier in children. Nonetheless, these differences do not have major effects on the quality of SARS-CoV-2-specific antibody responses. Our findings reveal that better early control of inflammation as observed in children may be key for rapidly controlling infection and limiting the disease course.
SCOPUS: ar.j
info:eu-repo/semantics/published
Databáze: OpenAIRE
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