| Autor: |
Hinamoto, Norikazu, Maeshima, Yohei, Saito, Daisuke, Yamasaki, Hiroko, Tanabe, Katsuyuki, Nasu, Tatsuyo, Watatani, Hiroyuki, Ujike, Haruyo, Kinomura, Masaru, Sugiyama, Hitoshi, Sonoda, Hikaru, Kanomata, Naoki, Sato, Yasufumi, Makino, Hirofumi |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Acta medica Okayama. 68(4) |
| ISSN: |
0386-300X |
| Popis: |
Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r＝0.48, p＝0.001) or cortex (r＝0.64, p＜0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r＝0.34, p＝0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r＝0.44, p＝0.01) or medulla (r＝0.63, p＝0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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