Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Lung Infections
| Autor: | Trottein, François, Paget, Christophe |
|---|---|
| Přispěvatelé: | Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL], Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 [CEPR], Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), CHU Lille, Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by the Inserm, the CNRS, the University of Lille Nord de France, the Pasteur Institute of Lille, and the Institut National du Cancer (INCa, under reference R08046EE/RPT08003EEA and R13071EE/RPT13001EEA)., We apologize to colleagues whose works could not be cited due to space constraints. CP is supported by the INSERM and FT by the CNRS., Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), TROTTEIN, François |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
[SDV]Life Sciences [q-bio]
Immunology Pneumonia Viral MESH: Pneumonia Viral/immunology chemical and pharmacologic phenomena Review Adaptive Immunity Immunotherapy Adoptive [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity MESH: Antigens CD1d/analysis lung Minor Histocompatibility Antigens MESH: Natural Killer T-Cells/immunology MESH: Histocompatibility Antigens Class I/analysis Pneumonia Bacterial Animals Humans MESH: Animals viruses bacteria Tuberculosis Pulmonary [SDV.IMM.II] Life Sciences [q-bio]/Immunology/Innate immunity ComputingMilieux_MISCELLANEOUS Vaccines MESH: Humans MESH: Tuberculosis Pulmonary/immunology Histocompatibility Antigens Class I MESH: Vaccines/therapeutic use MESH: Minor Histocompatibility Antigens/analysis biochemical phenomena metabolism and nutrition Immunity Innate infection natural killer T cells MESH: Immunotherapy Adoptive mucosal-associated invariant T cells Natural Killer T-Cells MESH: Mucosal-Associated Invariant T Cells/immunology mucosal immunity MESH: Immunity Innate MESH: Pneumonia Bacterial/immunology immunotherapy Antigens CD1d MESH: Adaptive Immunity |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Frontiers, 2018, 9, ⟨10.3389/fimmu.2018.01750⟩ Frontiers in Immunology, Frontiers, 2018, 9, pp.1750. ⟨10.3389/fimmu.2018.01750⟩ Frontiers in Immunology, 2018, 9, pp.1750. ⟨10.3389/fimmu.2018.01750⟩ |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2018.01750⟩ |
| Popis: | International audience; The immune system has been traditionally divided into two arms called innate and adaptive immunity. Typically, innate immunity refers to rapid defense mechanisms that set in motion within minutes to hours following an insult. Conversely, the adaptive immune response emerges after several days and relies on the innate immune response for its initiation and subsequent outcome. However, the recent discovery of immune cells displaying merged properties indicates that this distinction is not mutually exclusive. These populations that span the innate-adaptive border of immunity comprise, among others, CD1d-restricted natural killer T cells and MR1-restricted mucosal-associated invariant T cells. These cells have the unique ability to swiftly activate in response to non-peptidic antigens through their T cell receptor and/or to activating cytokines in order to modulate many aspects of the immune response. Despite they recirculate all through the body via the bloodstream, these cells mainly establish residency at barrier sites including lungs. Here, we discuss the current knowledge into the biology of these cells during lung (viral and bacterial) infections including activation mechanisms and functions. We also discuss future strategies targeting these cell types to optimize immune responses against respiratory pathogens. |
| Databáze: | OpenAIRE |
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