Intradermal tests with drugs: an approach to standardization

Autor: Barbaud, Annick, Weinborn, Marie, Garvey, Lene Heise, Testi, Sergio, Kvedariene, Violeta, Bavbek, Sevim, Mosbech, Holger, Gomes, Eva, Aberer, Werner, Elberink, Hanneke N G Oude, Torres, Maria Jose, Ponvert, Claude, Ayav, C, Gooi, Jimmy, Brockow, Knut
Přispěvatelé: Groningen Research Institute for Asthma and COPD (GRIAC), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de dermatologie et allergologie [CHU Tenon], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Dermatologie et Allergologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre hospitalier [Valenciennes, Nord], Copenhagen University Hospital, Vilnius University [Vilnius], Ankara University School of Medicine [Turkey], Centro Hospitalar do Porto, Medical University Graz, University Medical Center Groningen [Groningen] (UMCG), University of Groningen [Groningen], Universidad de Málaga [Málaga] = University of Málaga [Málaga], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Pneumologie Allergologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Service d'Epidémiologie et Evaluations Cliniques [CHRU Nancy] (Pôle S2R), King's College Hospital (KCH), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Gestionnaire, Hal Sorbonne Université
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Frontiers in medicine, Lausanne : Frontiers Media S.A., 2020, vol. 7, art. no. 156, p. [1-8]
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Frontiers in Medicine, 7:156. Frontiers Media S.A.
Frontiers in Medicine
Frontiers in Medicine, Frontiers media, 2020, 7, pp.156. ⟨10.3389/fmed.2020.00156⟩
Barbaud, A, Weinborn, M, Garvey, L H, Testi, S, Kvedariene, V, Bavbek, S, Mosbech, H, Gomes, E, Aberer, W, Elberink, H N G O, Torres, M J, Ponvert, C, Ayav, C, Gooi, J & Brockow, K 2020, ' Intradermal Tests With Drugs : An Approach to Standardization ', Frontiers in Medicine, vol. 7, 156 . https://doi.org/10.3389/fmed.2020.00156
ISSN: 2296-858X
2095-0217
DOI: 10.3389/fmed.2020.00156⟩
Popis: Background: Intradermal tests (IDTs) are performed and interpreted differently in drug allergy centers making valid comparison of results difficult. Objective: To reduce method-related and intercenter variability of IDTs by the introduction of a standardized method. Materials and methods: In 11 centers of the European Network for Drug Allergy, IDTs were prospectively performed with saline and with amoxicillin (20 mg/ml) using (1) the local method and (2) the standardized European Network in Drug Allergy (ENDA) method (0.02 ml). The diameters of the initial injection wheal (Wi) for the different volumes and sites injected obtained from each center were analyzed. Results: The most reproducible method was to fill a syringe with test solution, then expel the excess fluid to obtain exactly 0.02 ml. The median Wi diameter with 0.02 ml injection using the standardized method was 5 mm [range 2-10 mm; interquartile range (IQR) 5-5 mm; n = 1,096] for saline and 5 mm (range 2-9 mm; IQR = 4.5-5 mm; n = 240) for amoxicillin. IDT injection sites did not affect the Wi diameter. Training improved precision and reduced the variability of Wi diameters. Conclusion: Using the standardized IDT method described in this multicenter study helped to reduce variability, enabling more reliable comparison of results between individuals and centers. info:eu-repo/semantics/publishedVersion
Databáze: OpenAIRE
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