Evidence for a possible anatomical subsite-mediated effect of tobacco in oral potentially malignant disorders and carcinoma

Autor:	Pentenero, Monica, Giaretti, W, Navone, R, Rostan, Isabella, Gassino, L, Broccoletti, Roberto, Arduino, PAOLO GIACOMO, Malacarne, D, Gandolfo, Sergio
Rok vydání:	2011
Předmět:	Male Gingival Neoplasms Palatal Neoplasms Smoking Age Factors Mouth Mucosa Middle Aged Tongue Neoplasms Cheek Sex Factors Erythroplasia Lip Neoplasms Carcinoma Squamous Cell Humans Female Mouth Neoplasms Disease Susceptibility Leukoplakia Oral Mouth Floor Precancerous Conditions Aged
Zdroj:	Journal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 40(3)
ISSN:	1600-0714
Popis:	To test the hypothesis that cigarette smokers develop oral potentially malignant disorders or carcinomas in preferential anatomical subsites.The association of smoking habit with the presence of oral lesions in specific anatomical subsites was assessed in 123 patients using the odds ratio analysis.When compared to all the other subsites, the relative frequency of smokers with lesions was higher in the buccal mucosa and in the floor of the mouth (FOM) (P=0.002 and P=0.005), while it was lower in the tongue (P0.0005). Smokers were about 7 years younger than non-smokers (P=0.008).The association of smoking and age suggests that smoking may contribute to generate a field of injury that leads to lesions in shorter periods than other causes. The stronger relationship of smoking with lesions in the buccal mucosa and FOM than in the tongue suggests that tissue characteristics mediate the effects of tobacco.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::21a0c10123c3abb3c827709b035ae84a https://pubmed.ncbi.nlm.nih.gov/21198867 Zobrazit plný text záznamu Plný text